Simultaneous quantitative analysis of mebendazole polymorphs A–C in powder mixtures by DRIFTS spectroscopy and ANN modeling

Mebendazole crystal forms in tablet formulations. An ATR-FTIR/chemometrics approach to polymorph assignment

“…2a) were analyzed and their most significant bands are detailed in Table 1. The results were in full agreement with the literature [7,22,23,31]. Fig.…”

“…Form B was prepared by dissolution of the drug (100 mg) in refluxing chloroform (200 ml), followed by slow cooling and recovery of the crystals after solvent evaporation under reduced pressure in a Büchi R-114 rotary evaporator (Büchi Labortechnik, Flawil, Switzerland) [23,39]. Several batches were combined in order to obtain enough amount of the compound for the experiments.…”

“…More recently, second derivative DRIFTS [23] and attenuated total reflection (ATR) [7] data have been combined with artificial neural networks to quantitate Forms A and C of MEB. On the other hand the ability of Raman spectroscopy [24] and the near infrared-PLS combination [25], to identify the crystal forms of MEB have also been examined.…”

Polymorphism and Solvatomorphism 2010

“…60 Diffuse reflectance IR spectroscopy and artificial neural network modeling have been combined to yield a quantitative method for the three polymorphic forms of mebendazole in samples of the bulk drug substance and in samples of a suspension formulation. 61 Analysis of high-quality XRPD data has been used in a number of cases to obtain the crystal structures of polymorphic forms for which single crystals of adequate quality were not available. Such work included the monoclinic form-I of clopidogrel bisulfate, 62 the monoclinic form-II of racemic ibuprofen, 63 the triclinic form-A of mebendazole, 64 the monoclinic form-I and orthorhombic form-II of benfluorex hydrochloride, 65 and the monoclinic $-form of phenazepam.…”

Quantitative analysis of mebendazole polymorphs in pharmaceutical raw materials using near-infrared spectroscopy

“…It has enough solubility to ensure optimal drug bioavailability and is stable at room temperature up to ±179ºC [1,2,14]. However, all three of these polymorphic forms have been found in pharmaceutical raw material and formulae commercialized worldwide [15][16][17][18].…”