Simultaneous quantitative analysis of oxcarbazepine and 10,11-dihydro-10-hydroxycarbamazepine in human plasma by liquid chromatography–electrospray tandem mass spectrometry

Maia, Maria Bernadete de Sousa; Nascimento, Demétrius Fernandes do; Martins, Ismael Leite; Cunha, Adriano N.; Lima, Francisco Evanir Gonçalves de; Bezerra, Fernando Antônio Frota; Moraes, Manoel Odoríco de; Moraes, Maria Elisabete Amaral de

doi:10.1016/j.jpba.2007.08.001

Cited by 23 publications

(11 citation statements)

References 31 publications

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“…Several papers deal with the determination of OXCBZ and its metabolites or other CNS drugs in human plasma [270][271][272][273][274][275][276][277][278][279][280][281][282][283], saliva [284][285][286] and urine [287,288] from epileptic patients. Currently, HPLC with UV detector is much more widespread [271-276, 278, 280, 281, 283-288]; other papers used HPLC coupled with mass spectrometry [270] or diode array detection (DAD) [279,282].…”

Section: Methods Of Analysismentioning

confidence: 99%

“…Currently, HPLC with UV detector is much more widespread [271-276, 278, 280, 281, 283-288]; other papers used HPLC coupled with mass spectrometry [270] or diode array detection (DAD) [279,282]. One paper demonstrates the separation of OXCBZ and its metabolites from biological sample by means of capillary electrokinetic chromatography (MEKC) [289].…”

Section: Methods Of Analysismentioning

confidence: 99%

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Antipsychotic and Antiepileptic Drugs in Bipolar Disorder: The Importance of Therapeutic Drug Monitoring

Musenga

Saracino

Sani³

et al. 2009

CMC

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Bipolar disorder (BD) is a long-term illness with mood swings which are characterized by recurrent episodes of mania/hypomania and depression, with variable interpolations of relatively asymptomatic periods, called euthymic, in which, however, some psychopathological symptoms may persist. Although mood stabilizers, such as lithium, are the first-line treatment for the prevention of new BD episodes, combination therapy has become the standard of care for BD patients. Besides lithium, the use of a mood stabilizer along with an atypical antipsychotic is recommended in many patients. Recently, atypical antipsychotics (quetiapine, olanzapine, risperidone and aripiprazole) and antiepileptic agents (valproate, lamotrigine and oxcarbazepine) are increasingly used as mood stabilizers. To reduce side effects and optimize treatment it is important to perform accurate monitoring of drug blood levels in these patients, who are often treated with multiple drugs. Therapeutic drug monitoring (TDM) is in fact a powerful tool that, starting from clinical-chemical correlation data, allows to tailor-cut treatment to the specific needs of individual patients; hence the need to have reliable analytical methods available for the determination of plasma levels of drugs and their metabolites. Analyses of biological samples are mainly carried out using high-performance liquid chromatography (HPLC) coupled with different detectors, capillary electrophoresis and gas-chromatography. Various procedures are employed to remove biological interferences before analyzing the samples. This review focuses on currently available analytical TDM methods for atypical antipsychotics and antiepileptic agents used in the treatment of patients with bipolar disorder. Advantages and limitations of the various analytical methods will be reviewed and discussed, together with an evaluation of the role of TDM.

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Section: Methods Of Analysismentioning

confidence: 99%

Section: Methods Of Analysismentioning

confidence: 99%

Antipsychotic and Antiepileptic Drugs in Bipolar Disorder: The Importance of Therapeutic Drug Monitoring

Musenga

Saracino

Sani³

et al. 2009

CMC

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“…A variety of sample preparation methods have been employed to clean up samples prior to anticonvulsant measurement. Anticonvulsants are present in relatively high concentrations in plasma so protein precipitation is generally sufficient for their quantification, LLE [73,74] or SPE [75] may be necessary if quantification of metabolites or multiple drugs is required.…”

Section: Anticonvulsantsmentioning

confidence: 99%

Therapeutic drug monitoring and LC–MS/MS

Adaway

Keevil

2012

Journal of Chromatography B

130

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“…MS/MS tuning experiments displayed daughter scan spectra of OXC and its metabolites in according to those reported in literature [10,12,19,21]. The most abundant ions from daughter ion experiments were selected to obtain MRM transitions as more sensitive as possible.…”

Section: Ms Developmentmentioning

confidence: 99%

“…Recently, OXC and MHD have been also analysed on rat brain microdialysis and human plasma samples using tandem mass spectrometry. In these works the authors used a microbore and nanobore LC/MS/MS with a total run time over than 15 and 20 min, respectively, in rat brain samples [19,20] and a method with a run time of 3 min for the analysis of OXC and MHD in human plasma [21].…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a LC/MS/MS method for simultaneous quantification of oxcarbazepine and its main metabolites in human serum

Paglia

D’Apolito

Garofalo

et al. 2007

Journal of Chromatography B

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Simultaneous quantitative analysis of oxcarbazepine and 10,11-dihydro-10-hydroxycarbamazepine in human plasma by liquid chromatography–electrospray tandem mass spectrometry

Cited by 23 publications

References 31 publications

Antipsychotic and Antiepileptic Drugs in Bipolar Disorder: The Importance of Therapeutic Drug Monitoring

Antipsychotic and Antiepileptic Drugs in Bipolar Disorder: The Importance of Therapeutic Drug Monitoring

Therapeutic drug monitoring and LC–MS/MS

Development and validation of a LC/MS/MS method for simultaneous quantification of oxcarbazepine and its main metabolites in human serum

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