Simultaneous Quantitative Determination of Codeine Phosphate, Chlorpheniramine Maleate Phenylephrine Hydrochloride and Acetaminophen in Pharmaceutical Dosage Forms Using Thin Layer Chromatography Densitometry

Alkaysi, H. N.; Salem, Mutaz S.

doi:10.1080/00032718608066272

Cited by 16 publications

(7 citation statements)

References 5 publications

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“…Literature survey revealed few quantitative techniques like RP-HPLC [5][6][7][8][9][10][11][12][13][14][15][16], UV spectroscopy [17][18][19], TLC [20] methods for CPM and RP-HPLC method [21], UV spectroscopy [22] for LCF are available. So far to our present knowledge, no validated analytical high performance liquid chromatography (HPLC) method was available in literature for this combination in syrup formulation.…”

Section: -{2-[(4-chloro-phenyl)-phenylmethoxy]-ethyl}-piperidine (Fimentioning

confidence: 99%

Development and Validation of RP-HPLC Method for Simultaneous Estimation of Levocloperastine Fendizoate and Chlorpheniramine Maleate in their Combined Dosage Form

Meshram¹

2017

Austin J Anal Pharm Chem

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A simple and rapid RP-HPLC method has been developed and validated for the simultaneous determination of Levocloperastine fendizoate and Chlorpheniramine maleate syrup formulation. Resolution of the analytes was achieved within 10min, employing a mixture of 10mM mobile phase Buffer (pH 6.5): Acetonitrile (50:50, % v/v) as isocratic mobile phase, pumped at 1.0mL/ min through a C18 column (5µm particle size). The detection wavelength for the analytes was 227nm. The system suitability parameters were found to be acceptable. The linearity of response (r 2 >0.999) in the appropriate ranges (from 50% up to 150% of the expected concentrations of the analytes in the formulations), method accuracy (RSD<2.0%), repeatability and intermediate precision (RSD<2.0%), were confirmed. Robustness result indicates that the methods performance can withstand small variations in method parameters. Satisfactory results obtained in terms of analyte recovery and RSD, while analyzing marketed pharmaceutical preparations. Hence the method can be useful for regular analysis of this combination in marketed syrup formulation.

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Section: -{2-[(4-chloro-phenyl)-phenylmethoxy]-ethyl}-piperidine (Fimentioning

confidence: 99%

Development and Validation of RP-HPLC Method for Simultaneous Estimation of Levocloperastine Fendizoate and Chlorpheniramine Maleate in their Combined Dosage Form

Meshram¹

2017

Austin J Anal Pharm Chem

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“…According to review, phenylephrine hydrochloride was determination by several methods such as these recent spectrophotometry, 5 spectrophotometry method for estimating infinitesimal amounts of phenylephrine hydrochloride, 6 HPLC reversed-phase technique, 7 HPLC technique, 8 liquid chromatography technique, 9 thin layer chromatography technique, 10 voltammetric differential Pulse Method, 11 capillary electrophoresis method, 12 combining liquid chromatography and mass spectrometry techniques and comparing results with HPLC-UV, 13 micellar electrokinetic chromatography *Author for Correspondence: yahyaalbayti@yahoo.com method. 14 Several techniques used for determination drugs and pharmaceuticals.…”

Section: Introductionmentioning

confidence: 99%

Preparation of New Molecularly Imprinted Polymers and its Use in the Selective Extraction For Determination Phenylephrine Hydrochloride at Pharmaceuticals

Mahdi

Ameen

Al-Bayati

2019

ijddt

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This study was aimed at four electrodes were synthesized based on molecularly imprinted polymers (MIPs). Two MIPs were prepared by using phenylephrine hydrochloride (PPH) as the template, methyl methacrylate (MMA) as monomer as well as trimethylol propane tri methacrylate (TMPTMA) and ethylene glycol dimethacrylate (EGDMA) as cross linkers respectively and benzoyl peroxide as initiator. The same composition was used in the preparation of non-imprinted polymers (NIPs), but without the template (Phenylephrine hydrochloride). For the preparation of membranes, different plasticizers were used in the PVC matrix, such as Dioctyl phthalate (DOPH), dibutyl phthalate (DBPH), and nitrobenzene (NB). The characteristics studied are the slop, detection limit, lifetime, and linearity range of PPH–MIPs electrodes. Results obtained from selectivity measurements on interfering cations (K+, Ca+2, Al+3) and some pharmaceutical additives such as methylparaben, propylparaben, trisodium citrate showed no interfering with drug phenylephrine hydrochloride. The preparation electrodes have been shown good response including testing pharmaceutical analysis.

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“…The literature survey reveals that many analytical methods are reported for the determination of CP and CPM indi-vidually and in combination. The literature survey revealed spectroscopic [2][3][4][5] and chromatographic [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] methods.…”

Section: Introductionmentioning

confidence: 99%

Validated Stability Indicating RP-HPLC Method for Simultaneous Estimation of Codeine Phosphate and Chlorpheniramine Maleate from Their Combined Liquid Dosage Form

Kommana¹,

Basappa²

2013

Chromatography Research International

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The present paper describes the development of quick stability indicating RP-HPLC method for the simultaneous estimation of codeine phosphate and chlorpheniramine maleate in the presence of its degradation products, generated from forced degradation studies. The developed method separates codeine phosphate and chlorpheniramine maleate in impurities/degradation products. Codeine phosphate and chlorpheniramine maleate and their combination drug product were exposed to acid, base, oxidation, dry heat, and photolytic stress conditions, and the stressed samples were analysed by proposed method. The proposed HPLC method utilizes the Shimadzu HPLC system on a Phenomenex C 18 column (250 mm × 4.6 mm, 5 ) using a mixture of 1% o-phosphoric acid in water : acetonitrile : methanol (78 : 10 : 12) mobile phase with pH adjusted to 3.0 in an isocratic elution mode at a flow rate of 1 mL/min, at 23 ∘ C with a load of 20 L. The detection was carried out at 254 nm. The retention time of codeine phosphate and chlorpheniramine maleate was found to be around 3.47 min and 9.45 min, respectively. The method has been validated with respect to linearity, robustness, precision, accuracy, limit of detection (LOD), and limit of quantification (LOQ). The developed validated stability indicating HPLC method was found to be simple, accurate, and reproducible for the determination of instability of these drugs in bulk and commercial products.

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Simultaneous Quantitative Determination of Codeine Phosphate, Chlorpheniramine Maleate Phenylephrine Hydrochloride and Acetaminophen in Pharmaceutical Dosage Forms Using Thin Layer Chromatography Densitometry

Cited by 16 publications

References 5 publications

Development and Validation of RP-HPLC Method for Simultaneous Estimation of Levocloperastine Fendizoate and Chlorpheniramine Maleate in their Combined Dosage Form

Development and Validation of RP-HPLC Method for Simultaneous Estimation of Levocloperastine Fendizoate and Chlorpheniramine Maleate in their Combined Dosage Form

Preparation of New Molecularly Imprinted Polymers and its Use in the Selective Extraction For Determination Phenylephrine Hydrochloride at Pharmaceuticals

Validated Stability Indicating RP-HPLC Method for Simultaneous Estimation of Codeine Phosphate and Chlorpheniramine Maleate from Their Combined Liquid Dosage Form

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