Simultaneous Ratio Derivative Spectrophotometric Determination of Paracetamol, Caffeine and Ibuprofen in Their Ternary Form

Abstract

A new, accurate, precise and economic two spectrophotometric methods for determination of Paracetamol (Par), Ibuprofen (Ibu), and Caffeine (Caf) were suggested. Those methods were the first and second ratio derivative spectrum using a double devisor. Par, Ibu, and Caf showed many useful peaks for their quantified determination. The validity of all analysis modes for determination of the three compounds, peak to baseline, peak area and peak to peak were according to ICH. The linearity of two methods was between 5 µg/ml as a lower concentration and 50 µg/ml as the highest concentration for three compounds. Recovery percentage was around 100% and relative standard deviation was less than 2.6%. The methods were applied successfully in the determination of Par, Ibu, and Caf in pure and pharmaceutical forms.

Conductometric, Spectrophotometric and Computational Investigation of Binary and Ternary Complexes of Co(II) and Cu(II) Bivalent Metal Ions with L-Valine Amino Acid and Paracetamol Drug

“…Upon light absorption, an π electron is excited from the ground state to the first excited state, and new absorption peaks of the formed complex (Para-M(II)) ions have been attributed to the d→d transition (17), as shown in (Table 2 and Figure 4).…”

“…Job's method of continuous variation (20,21), which is straightforward, quick, measurable, and valid, was employed to ascertain the stoichiometry and formation constants of Para-metal(ll) complexes by spectrophotometry. Metals and Para were mixed in various ratios ranging from 0.188:1 to 1:0.188, and the absorbance of each mixture was measured at the complexes' maxima (17,21).…”

“…However, unlike other combinations, paracetamol is not considered carcinogenic at the therapeutic dose. Also, it is not generally classified as a Non-steroidal Anti-inflammatory drug (NSAID) because it exhibits only weak anti-inflammatory activity (17). In a recently published paper by our group, the potentiometric method was used to determine the stability constant of Co(II) and Cu(II) binary and ternary complexes of L-Val ligands (18,19).…”

Combination of Artificial Neural Networks and Principal Component Analysis for the Simultaneous Quantification of Dyes in Multi-Component Aqueous Mixtures

“…Alsamarrai and S.T. Ameen [20] used derivative spectrophotometry for the simultaneous determination of Paracetamol, Caffeine, and Ibuprofen in their ternary mixture. In these investigations, the authors were able to analyze the mixtures with high overlapping absorption spectra without the need for the prior separation of the species.…”

Assessment of Ultrasound-Assisted Extraction of Caffeine and its Bioactivity

“…It is essentially obtained from coffee beans and leaves (Musa Ali et al, 2012), and also it can be found in tea leaves (Soni, 2019), cocoa beans (Grassia et al, 2019), and kola-nut (Umeda et al, 2020). This alkaloid is the most valuable, and its value comes from its importance to humans, where it works as a stimulant drug that improves attention (van Dam et al 2020) (Alsamarrai, 2022). However, the importance of caffeine as a pharmaceutical compound goes beyond just being a stimulant drug (Monteiro et al, 2019), where its effectiveness as a drug was studied for many medical cases to reduce their intensity or their possibility of accruing, such as consuming coffee may stimulate the gallbladder, which will reduce the risk of gallstones (Grosso et al, 2017).…”