Simultaneous Spectrophotometric Determination of Sacubitril and Valsartan in their Recently Approved Pharmaceutical Preparation

Abstract

Objectives: Simultaneous estimation of sacubitril and valsartan in their new pharmaceutical tablets by bivariate method and two multivariate methods namely; classical least square and principal component regression. Methods: (A) Bivariate method, where absorbance values were measured at two optimum wavelengths (220 nm and 250 nm). (B) Multivariate methods, where partial factorial design was constructed within the wavelength range from 210-290nm at 1 nm interval. Results: The bivariate method is based on simple mathematic algorithm using two optimum wavelengths for the analysis of the mixture. On the other hand, two multivariate methods considering all the variables at the same time have been used to improve the quality of spectral analysis of the mixture. Conclusion: The proposed methods have been successfully applied for the determination of the two drugs in Entresto ® tablets. Statistical comparisons between the obtained results and those obtained by the reported method have been performed showing no significant differences by applying t-test and F-test.

Spectrophotometric Determination Of Valsartan In Pure Form And In Its Pharmaceutical Preparations

“…The calibration curve for (Val) standard form with NBD-Cl showed the linearity at concentrations range of (0.4-14.8 μg/ml), as shown in Fig. (8).…”

“…1(a)], is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease, It is a reasonable initial treatment for high blood pressure, It is taken by mouth [1] , Valsartan is chemically described as N- (1-oxopentyl)-N- [[2′-(1H-tetrazol-5-yl) [1,1′-biphenyl]-4yl]methyl]-L-valine. Its empirical formula is C 24 H 29 N 5 O 3 , its molecular weight is 435.5 [5] , Several methods have been reported for determination of this drug, such as HPLC [8,12] , TLC [2,4] , HPTLC [11] , Voltammetry [6,10] , UV-Vis. Spectrophotometry [15,3] .…”

Ecological assessment and development of analytical methods for concurrent quantification of valsartan and sacubitril: whiteness comparative study based on relative scoring

“…While spectrouorimetric spectra depend on l ex and l em , spectrophotometric ones depend on l max only. 49 Hence, the reported spectrophotometric methods 7,8 have lower spectral resolution than the proposed methods. In addition, applying the synchronous mode improves their selectivity over the reported traditional spectrouorimetric ones.…”

“…5,6 This required establishing reliable analytical methods to analyze this combined therapy. Two spectrophotometric 7,8 and three HPTLC [9][10][11] methods have been reported for this purpose. In addition, LCZ696 was assayed by HPLC using many approaches.…”

Simultaneous Estimation of Sacubitril and Valsartan Combination of Drug in Tablet Dosage Form Using Hydrotropy by UV Spectrophotometry

“…ENTRESTO is a combined dosage form which contain sacubitril (SAC), a prodrug that results in neprilysin inhibition and valsartan (VAL) which is angiotensin II Type-1 receptor blocker), is the first medicine in this category. This combined drug (previously known as LCZ696) is also a useful antihypertensive drug (10). Sacubitril or Valsartan is a first-in-class angiotensin receptor-neprilysin inhibitor (ARNi) approved for the treatment of HF.…”