Simultaneous Stability-Indicating Determination of Phenylephrine Hydrochloride, Phenylpropanolamine Hydrochloride, and Guaifenesin in Dosage Forms by Reversed-Phase Paired-Ion High-Performance Liquid Chromatography

Schieffer, Gary W.; Hughes, D. E.

doi:10.1002/jps.2600720113

Cited by 25 publications

(8 citation statements)

References 17 publications

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“…This outcome is in good accordance with the research results of other groups obtained by colour analysis [30], by UV absorbance measurements after cationic exchange resin separation [31], by GC-MS following trimethylsilyl derivatization [29], by HPLC [32] and by LC/MS [33].…”

Section: Phenylephrine Hydrochloridesupporting

confidence: 93%

Investigating the degradation of the sympathomimetic drug phenylephrine by electrospray ionisation-mass spectrometry

Trommer¹,

Raith²,

Neubert³

2010

Journal of Pharmaceutical and Biomedical Analysis

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Section: Phenylephrine Hydrochloridesupporting

confidence: 93%

Investigating the degradation of the sympathomimetic drug phenylephrine by electrospray ionisation-mass spectrometry

Trommer¹,

Raith²,

Neubert³

2010

Journal of Pharmaceutical and Biomedical Analysis

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“…All three drugs are official in Indian pharmacopoeia (IP) [11] and British Pharmacopoeia (BP) [9] . The PCM, CPM and PH alone or in combination with other drugs are reported to be estimated by the spectrophotometric method [12] , [13] , [14] , [15] , derivative spectrophotometric method [16] , chemometric-assisted spectrophotometry [17] , HPLC [18] , [19] , thin layer chromatography (TLC) [20] , liquid chromatography–mass spectrometry (LC–MS) [21] , Fourier transform infrared spectroscopy (FT–IR) [22] , amperometric determination [23] , fluorimetry [24] , micellar electrokinetic chromatographic method [25] , electrophoresis [26] , liquid chromatography with two ultraviolet (UV) absorbance detectors [27] , and chemometric determination [28] .…”

Section: Introductionmentioning

confidence: 99%

Application of RP–HPLC method in dissolution testing and statistical evaluation by NASSAM for simultaneous estimation of tertiary combined dosages forms

Yogesh

Sharma

Sarma

et al. 2015

Journal of Pharmaceutical Analysis

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A dissolution method with robust high performance liquid chromatographic (HPLC) analysis for immediate release tablet formulation was developed and validated to meet the requirement as per International Conference on Harmonization (ICH) and United States Food and Drug Administration (USFDA) guidelines. The method involved the use of Agilent ZORBAX Eclipse XDB C18 column, and temperature was maintained at 30 °C. After optimization, the mobile phase was selected as phosphate buffer (KH2PO4, 30 mM) : ACN (60:40, v/v) with pH 3.0, and retention time Rt was found as 3.24, 4.16, and 2.55 min for paracetamol (PCM), chlorpheniramine maleate (CPM) and phenylephrine hydrochloride (PH) respectively at 265 nm and at a flow rate of 1 mL/min. The relative standard deviation (%RSD) for 6 replicate measurements was found to be less than 2%. Furthermore net analyte signal standard addition method (NASSAM) with spectrophotometer was performed for standard and liquid oral suspension. On the basis of selectivity, sensitivity and accuracy analysis, it was confirmed that this novel method could be useful for simultaneous estimation of the given drug combinations. Two-way analysis of variance (ANOVA) was applied for evaluating the statistical difference between the assay results obtained via both NASSAM and RP–HPLC methods and ultimately no significant difference was found between both the methods. All the methods and results were acceptable and confirmed that the method was suitable for intended use.

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“…8 used for active pharmaceutical ingredient ( Table 1). The PCM, 9 CPM 10 and PH 11 alone or in combination with other drugs is reported to be estimated by spectrophotometric method, [12][13][14][15][16] derivative spectrophotometric method, 17 chemometric-assisted spectrophotometric, 18 HPLC, [19][20] TLC, 21 LC-MS, 22 FT-IR, 23 amperometric determination, 24 fluorimetry, 25 micellar electrokinetic chromatographic method, 26 electrophoresis, 27 liquid chromatography with two UV absorbance detector 28 and chemometric determination. 29 As per literature survey, no analytical method has been developed by using derivative spectrophotometric method for this tertiary combination which is more reliable, simple, accurate and precise method for analysis of multicomponent mixture.…”

Section: Review Articlementioning

confidence: 99%

Simultaneous Estimation and Statistical Evaluation of Developed Validated Methods for Combined Drugs in Marketed Formulation

Yogesh¹,

Kaur²,

Vivek³

et al. 2013

Journal of Pharmaceutical Research

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We have developed rapid derivative methods for simultaneous estimation of paracetamol (PCM), chlorpheniramine maleate (CPM), and phenylephrine hydrochloride (PH) in pure and liquid dosage form. All methods are simple, accurate, rapid, precise, economical and reliable. Methods are third derivative zero crossing spectrophotometry (I), single divisor ratio spectra derivative spectrophotometry (II), double divisor ratio spectra derivative method (III) and Vierdot's method (IV). All the method utilizes methanol: 0.1N hydrochloric acid (1:9). For method I, II, III and IV Limit of Detection (L.O.D.) values were within 0.59-1.37 µg/mL, 0.60 -3.72 µg/mL and 0.71-3.22 µg/mL respectively; and Limit of Quantification (L.O.Q.) values were within 1.83-4.40 µg/mL, 2.11-11.91 µg/mL and 2.32-10.70 µg/mL for PCM, CPM and PH respectively. The linearity ranges for PCM, CPM and PH were found to be 1.5-15µg/mL, 5-40 µg/mL and 9-64 µg/mL respectively, showing regression coefficient values 0.999 < R 2 <1. Precision values were found less than 2% Relative Standard Deviation (R.S.D.) for all methods. The results obtained have been compared statistically via analysis of variance (ANOVA).

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Simultaneous Stability-Indicating Determination of Phenylephrine Hydrochloride, Phenylpropanolamine Hydrochloride, and Guaifenesin in Dosage Forms by Reversed-Phase Paired-Ion High-Performance Liquid Chromatography

Cited by 25 publications

References 17 publications

Investigating the degradation of the sympathomimetic drug phenylephrine by electrospray ionisation-mass spectrometry

Investigating the degradation of the sympathomimetic drug phenylephrine by electrospray ionisation-mass spectrometry

Application of RP–HPLC method in dissolution testing and statistical evaluation by NASSAM for simultaneous estimation of tertiary combined dosages forms

Simultaneous Estimation and Statistical Evaluation of Developed Validated Methods for Combined Drugs in Marketed Formulation

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