2020
DOI: 10.1101/2020.08.22.260612
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Simultaneous transcriptome and methylome profiles of single mouse oocytes provide novel insights on maturation and aging

Abstract: Background: Advanced maternal aging has become a worldwide public health issue that contributes to female fertility decline and significant risk to embryo development. Despite transcriptional and epigenetic alterations reported in oocyte maturation and development, the dynamics of gene expression and DNA dynamics associated with aging remain elusive. Here we generated simultaneous transcriptome and methylome profiles of mouse oocytes during aging and maturation at single-cell and single-base resolution to exam… Show more

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