Simultaneous Triple Primary Head and Neck Malignancies: A Rare Case Report

Singh, Ningombam Jiten; Tripathy, Nishikanta; Roy, Paromita; Manikantan, Kapila; Arun, Pattatheyil

doi:10.1007/s12105-015-0664-7

Cited by 13 publications

(9 citation statements)

References 12 publications

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“…[ 2 ] We found only 2 reports in the English literature reporting simultaneous DTC and NHL. Rizkallah et al [ 3 ] reported similar case, whereas Singh et al [ 4 ] published recently a case with triple malignancies—laringeal cancer, DTC, and NHL. Although it is different from our case, Guzzo et al [ 5 ] reported 33 cases with synchronous DTC and squamous cell carcinoma of head and neck for the period 1975 to 2004, of which 31 were diagnosed during the pathological examination.…”

Section: Discussionmentioning

confidence: 99%

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Synchronous papillary thyroid cancer and non-Hodgkin lymphoma

et al. 2018

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Rationale:Differentiated thyroid cancer is the most common endocrine malignancy with concomitant hematological malignancy in 7%.Patient concerns:We present a case of a synchronous papillary thyroid cancer and a follicular variant of non-Hodgkin lymphoma and discuss the possible diagnostic and treatment dilemmas.Diagnosis:A 48-year-old female was reffered to our hospital with diagnosis „thyroid cancer“. Due to a history compatable of synchronous lymphoproliferative disease we performed a computed tomography, which revealed multiple enlarged lymph nodes in the neck, mediastinum, axilla and abdomen.Interventions:A total thyroidectomy with dissection of the central compartment was performed. The microscopic examination of thyroid gland revealed multifocal papilary thyroid cancer and metastaes from the same cancer plus aggressive follicular B-cell non-Hodgkin lymphoma in the lymph nodes. Despite the classic approach „solid cancer first“, due to the advanced stage of lymphoma we first started the chemotherapy of NHL. She received 8 cycles of CHOP and I131 therapy with 129 mCi. Because of incomplete response 4 cycles Mabthera plus Bendamustin were added. The follow-up PET scan revealed complete remission of lymphoma and bilaterally enlarged single cervical lymph nodes, previously known to be iodine positive on I131-SPECT/CT. She was sheduled for bilateral radical neck LND.Outcomes:Complete remission of NHL and residual single metastatic cervical lymph nodes requiring bilateral radical neck LND.Lessons:The synchronous DTC and NHL is rare. To date, there is no standardized approach due to lack of experience. We suggest lymphoma first approach with synchronized and tailored multidisciplinary efforts. The molecular mechanisms of this link are poorly understood and yet remain to be elucidated.

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Section: Discussionmentioning

confidence: 99%

“…Despite the classic approach “solid cancer first,” due to the relatively good prognosis of PTC [ 4 ] and the advanced stage of NHL with a pronounced clinical manifestation and aggressive course, we first started the chemotherapy of NHL similar to other authors. [ 3 ]…”

Section: Discussionmentioning

confidence: 99%

Synchronous papillary thyroid cancer and non-Hodgkin lymphoma

et al. 2018

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“…Cancer that occurs within a year after another cancer was detected is defined as simultaneous cancer, and cancer occurring after 1 year of another is defined as heterochronous cancer; our study adopted this definition. There are some reports of simultaneous multiple primary cancers (15,16). In this study, the rate of simultaneous multiple primary cancers was 28.6% and the rate of heterochronous multiple primary cancers was 71.4%.…”

Section: Discussionmentioning

confidence: 52%

Investigation of multiple primary cancers in patients with bone and soft tissue primary malignancies: A retrospective, institution‑based study

et al. 2020

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In the aging society in Japan, the occurrence of multiple primary cancers has recently increased due to an increase in life expectancy and increased development in cancer diagnostic technology and improvement in treatment outcomes. However, few reports have focused on multiple primary cancers in patients with bone and soft tissue tumors. The present study aimed to analyze the clinical characteristics of patients with multiple malignancies of the bone and soft tissue.

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“…The prognosis of MPNs is better than that of recurrent and metastatic cancers [16]. In summary, to our knowledge, simultaneous triple primary neoplasms have an extremely low occurrence [17]. The exact etiology of MPNs is still unknown and we suspect that in this case, a diet high in salty and pickled foods was a major contributing factor.…”

Section: Discussionmentioning

confidence: 91%