1965
DOI: 10.1152/jappl.1965.20.4.611
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Simultaneous uptake of N2O and cyclopropane in man as a test of compartment model

Abstract: An experiment involving simultaneous pulmonary uptake of nitrous oxide and cyclopropane is analyzed for compatibility with the perfusion-limited multicompartment model of inert gas uptake. These test gases have approximately equal solubilities in body watery tissues (blood, muscle, viscera, etc.) but an approximately 1-to-8 ratio of solubility in fat. Therefore, the measured difference in time course of pulmonary uptake provides a sensitive test of the mechanism of adipose tissue uptake of these gases. The exp… Show more

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Cited by 29 publications
(17 citation statements)
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“…These errors arise from diffusion processes by which ^khypton is exchanged between subcutaneous and cutaneous tissues. Intercompartmental exchange has previously been calculated by Perl et al These authors assumed that the exchange between adjacent tissue compartments was only by diffusion across the boundary between tissues (15)(16)(17)(18)(19) and not by transport via blood streaming between tissues. Observations in the present study, however, indicate that such a blood transport mechanism is also of importance.…”
Section: Discussionmentioning
confidence: 99%
“…These errors arise from diffusion processes by which ^khypton is exchanged between subcutaneous and cutaneous tissues. Intercompartmental exchange has previously been calculated by Perl et al These authors assumed that the exchange between adjacent tissue compartments was only by diffusion across the boundary between tissues (15)(16)(17)(18)(19) and not by transport via blood streaming between tissues. Observations in the present study, however, indicate that such a blood transport mechanism is also of importance.…”
Section: Discussionmentioning
confidence: 99%
“…Figure 2 shows the averaged equilibration curves for cyclopropane for the infant group and the child group. It also shows an averaged adult cyclopropane equilibration curve from a previously reported study (Rackow et al, 1965). At 10 minutes, the infant curve reached an FE/FI ratio of 0.9; the child curve was below this and the adult curve still lower.…”
Section: Methodsmentioning
confidence: 67%
“…For each group, equilibrium curves for both test gases were constructed from the averaged FE/FI values. These curves were used for comparing the paediatric groups with each other and with previous curves for adults (Rackow et al, 1965).…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…The term "diffusion anoxia" is, however, well established and deserves retention for its specificity of implication. Rackow, Salanitre and Frumin (1961) further considered this problem. They pointed out that there would be in addition to the decrease in inspiratory ventilation an increase in expiratory ventilation, again necessitated by the requirement of constant total pressure.…”
Section: The First Few Minutesmentioning
confidence: 99%