During 2022 and 2023, Industry 5.0 attracted a lot of attention. Many articles and papers regarding the basics of Industry 5.0, its pillars, and a comparison of Industry 5.0 and Industry 4.0, Society 5.0, and Operator 5.0 have been published. Although the concept of Industry 5.0 is relatively new, companies from developed countries that have a high level of implementation of Industry 4.0 have already started the transition to Industry 5.0. Even though Industry 5.0 enables developing countries to become a part of developed countries’ value chains, it is not known which path to Industry 5.0 developing countries are taking. To fill this gap, the authors proposed research questions regarding the key indicators for measuring the levels of implementation of Industry 5.0 approaches in the manufacturing sector of the Republic of Serbia. This research includes insights from 146 manufacturing companies, gathered in 2022 as a part of the European Manufacturing Survey. The main findings of this study show that the most important indicator when it comes to human-centricity is training and competence development of production employees with a task-specific focus; the implementation of measures for improving efficiency in material consumption is significant for achieving sustainability; and the use of standardized and detailed work instructions is crucial in order to become resilient.