Simvastatin blunts the increase of circulating adhesion molecules after coronary artery bypass surgery with cardiopulmonary bypass

Systemic vascular cell adhesion molecule-1 predicts the occurrence of post-operative atrial fibrillation

“…The potential therapeutic scope of the relationship between adhesion molecules and atrial fibrillation has been recently explored by Goette et al [42], who demonstrated that angiotensin II receptor blockers substantially decrease VCAM-1 expression in an animal model of atrial fibrillation. Similarly, statins are capable of blunting the increase of circulating adhesion molecules after heart surgery [43], which may explain-at least partially-their effect on preventing POAF [44,45].…”

Diagnosis and treatment of transplantation-associated thrombotic microangiopathy: real progress or are we still waiting?

“…In addition to the agents used to treat TA-TMA described above, there are a number of compounds being developed or already in use for other disorders that may be useful for attenuating the effects of endothelial injury in the setting of hematopoietic SCT (see Table 5). These include statins, which reduce the endothelial inflammatory response to myocardial ischemia and percutaneous interventions [107][108][109][110] and iloprost, a prostacyclin analogue that has been shown to reduce plasma markers of endothelial cell activation and injury in patients with rheumatoid arthritis. 111 Endothelin receptor antagonists, such as bosentan, have been shown in vitro to ameliorate microvascular injury induced by CYA 112 and to protect against ischemia/ reperfusion induced endothelial injury in vivo.…”

The influence of preoperative pharmacotherapy on the appearance of postoperative atrial fibrillation in patients undergoing isolated coronary artery bypass grafting

“…44 Finally, we found that preoperative statin use was associated with a 60% risk reduction in POAF incidence. The antiarrhythmic mechanism of statins can possibly be explained by their effects on inflammation 45,46,47,48 , antioxidant effects 49,50 , antiarrhythmic effects due to ion channel stabilization 51 , a role in extracellular matrix modulation 52 , an inhibition of synthesis of isoprenoids that are significant for the posttranslational modification of such signalling molecules as Rho, Rac, and Ras…”