2005
DOI: 10.1161/01.cir.0000164260.82417.3f
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Simvastatin Versus Ezetimibe

Abstract: Background-Statins may exert important pleiotropic effects, ie, improve endothelial function, independently of their impact on LDL cholesterol. In humans, however, pleiotropic effects of statins have never been unequivocally demonstrated because prolonged statin treatment always results in reduced LDL cholesterol levels. We therefore tested the hypothesis that similar reductions in LDL cholesterol with simvastatin and ezetimibe, a novel cholesterol absorption inhibitor, result in different effects on endotheli… Show more

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Cited by 385 publications
(100 citation statements)
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References 68 publications
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“…3 In this issue of Circulation, Landmesser et al report that with equal lowering of LDL-cholesterol by simvastatin or ezetimibe, only simvastatin improved endothelial function (as measured by flow-dependent dilation in the radial artery) in patients with congestive heart failure (CHF). 4 This study supports the view that statins provide clinical cardiovascular benefits beyond lipid modification.…”
Section: See P 2356supporting
confidence: 81%
“…3 In this issue of Circulation, Landmesser et al report that with equal lowering of LDL-cholesterol by simvastatin or ezetimibe, only simvastatin improved endothelial function (as measured by flow-dependent dilation in the radial artery) in patients with congestive heart failure (CHF). 4 This study supports the view that statins provide clinical cardiovascular benefits beyond lipid modification.…”
Section: See P 2356supporting
confidence: 81%
“…However, the impact of pleiotropic effects for clinical benefit is a matter of intense debate. Although data from meta-analyses of lipid-lowering trials suggest that lipid modification alone accounts for the clinical benefits associated with statin therapy, recent studies have implied that statin-induced LDL cholesterol reduction may in fact be more beneficial compared with non-statin-induced LDL cholesterol reduction (Brouilette et al, 2007;Landmesser et al, 2005;Fichtlscherer et al, 2006;Rossebø et al, 2008). These pleiotropic effects have even been suggested to contribute to neuroprotection (Kivipelto et al, 2005).…”
Section: Discussionmentioning
confidence: 99%
“…40 Mevalonic acid was converted to the corresponding lactone, extracted into ethyl acetate, purified via silica gel chromatography, and eluted with dichloromethane:methanol (95:5 v/v). After derivatization with N-methyl-N-trimethylsilyltrifluoro-acetamide (containing 1% trimethylchlorosilane)/pyridine (2:1 v/v) at room temperature, samples were analyzed via electron ionization gas chromatography/mass spectrometry in single-ion-monitoring mode using ions at m/z 233 for the target and m/z 237 for the internal standard ion.…”
Section: Methodsmentioning
confidence: 99%