Sinapic acid ameliorate cadmium-induced nephrotoxicity: In vivo possible involvement of oxidative stress, apoptosis, and inflammation via NF-κB downregulation

Ansari, Mushtaq A.; Raish, Mohammad; Ahmad, Ajaz; Alkharfy, Khalid M.; Ahmad, Sheikh F.; Attia, Sabry M.; Alsaad, Abdulaziz M.S.; Bakheet, Saleh A.

doi:10.1016/j.etap.2017.02.014

Cited by 95 publications

(70 citation statements)

References 48 publications

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“…(maximum 1 μ l of Tween 20 per 1 ml of water). The doses were within the range of doses administered in previous experimental studies of sinapic acid [ 27 , 28 , 30 , 31 , 33 ] and estradiol [ 36 ] in rats. The SHAM and OVX control rats received water with the same amount of Tween 20, in the same volume of 2 ml/kg p.o.…”

Section: Methodsmentioning

confidence: 85%

“…Sinapic acid, a hydroxycinnamic acid derivative, has antioxidant activity. There are reports on its numerous peripheral activities (anti-inflammatory [ 25 ], hypoglycemic [ 26 , 27 ], cardioprotective [ 28 , 29 ], hepatoprotective [ 30 ], and nephroprotective [ 31 ]) and central activities (neuroprotective [ 32 – 34 ], anticonvulsant [ 34 ], and anxiolytic [ 35 ]).…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Sinapic Acid on the Development of Metabolic Disorders Induced by Estrogen Deficiency in Rats

Zych

Kaczmarczyk-Sedlak

Wojnar

et al. 2018

Oxidative Medicine and Cellular Longevity

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Sinapic acid is a natural phenolic acid found in fruits, vegetables, and cereals, exerting numerous pharmacological effects. The aim of the study was to investigate the influence of sinapic acid on biochemical parameters related to glucose and lipid metabolism, as well as markers of antioxidant abilities and parameters of oxidative damage in the blood serum in estrogen-deficient rats. The study was performed on 3-month-old female Wistar rats, divided into 5 groups, including sham-operated control rats, ovariectomized control rats, and ovariectomized rats administered orally with estradiol (0.2 mg/kg) or sinapic acid (5 and 25 mg/kg) for 28 days. The levels of estradiol, progesterone, interleukin 18, insulin, glucose, fructosamine, lipids, and enzymatic and nonenzymatic antioxidants (superoxide dismutase, catalase, and glutathione); total antioxidant capacity; and oxidative damage parameters (thiobarbituric acid-reactive substances, protein carbonyl groups, and advanced oxidation protein products) were determined in the serum. Estradiol counteracted the carbohydrate and cholesterol metabolism disorders induced by estrogen deficiency. Sinapic acid increased the serum estradiol concentration; decreased insulin resistance and the triglyceride and total cholesterol concentrations; and favorably affected the parameters of antioxidant abilities (reduced glutathione, superoxide dismutase) and oxidative damage (advanced oxidation protein products).

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Section: Methodsmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

The Effects of Sinapic Acid on the Development of Metabolic Disorders Induced by Estrogen Deficiency in Rats

Zych

Kaczmarczyk-Sedlak

Wojnar

et al. 2018

Oxidative Medicine and Cellular Longevity

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“…Previous studies have reported the positive impact of SA on renal diseases. For example, Ansari et al (2017) documented that SA at a dose of 10-20 mg/kg bw improved renal function in cadmium-induced nephrotoxicity via an improvement in antioxidant status and downregulation of renal inflammatory biomarkers. The same research group also observed that SA pretreatment mitigates gentamicin-induced renal damage by the downregulation of oxidative stress, inflammation, and apoptosis in the kidney (Ansari et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Antihyperuricemic effect of dietary polyphenol sinapic acid commonly present in various edible food plants

et al. 2019

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The present study was conducted to evaluate the antihyperuricemic effect of sinapic acid (SA). The results showed that SA potently inhibited xanthine oxidase (XOD) in a dose-dependent manner by entering the enzyme active site and thwarting the entrance of the substrate. These results were further confirmed by the quantum chemical descriptors analysis and 1 H NMR titration analysis. The in vivo results indicated that SA not only has the potential to inhibit serum and hepatic XOD (p < .05), but also remarkably lowered serum and urine uric acid levels at 50 and 100 mg/kg bw.Furthermore, SA regulated serum creatinine and blood urea nitrogen levels to normal and lowered inflammation in the renal tubules. Thus, the utilization of SA as an antihyperuricemic agent may have considerable potential for the development of functional foods for the possible treatment of hyperuricemia.

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“…Sinapic acid (4-hydroxy-3,5-dimethoxy cinnamic acid) is a derivative of cinnamic acid with a 3,5dimethoxyl and 4-hydroxyl derivative in the phenyl group of cinnamic acid. Previous studies have reported various pathological symptoms associated with oxidative stress, inflammation, cancer, diabetes, neurodegeneration, and anxiety to have been induced by sinapic acid (Ansari et al 2017;Balaji et al 2014;Cherng et al 2013;Zare et al 2015;Yoon et al 2007). This study examined the cytoprotective effects of sinapic acid on cell damage by UVB.…”

Section: Introductionmentioning

confidence: 99%

Cytoprotective effects of sinapic acid on human keratinocytes (HaCaT) against ultraviolet B

Kim

Lim

2018

biomed dermatol

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Background: Sinapic acid is a phenolic compound in various plants, including spices, berries, citrus fruits, vegetables, grains, and oil seeds. It has been studied mainly for the various pathological symptoms it induces related to its anticancer, antioxidant, and neuroprotective effects. However, little has been studied about sinapic acid in human keratinocytes (HaCaT). Therefore, this study examined its reactive oxygen species (ROS) scavenging capacity, protective effect against DNA damage, and DNA repair mechanism. Methods: To confirm the protective effects of sinapic acid on HaCaT irradiated by ultraviolet (UV) B, this study used the water-soluble tetrazolium salts (WST)-1 assay to determine the cytotoxicity of sinapic acid for verifying the cell survival rate and dichlorofluorescein diacetate (DCF-DA) to measure the changes in the concentration of ROS generated by UVB. This study also used the comet assay, cyclobutane pyrimidine dimer (CPD) formation, and malondialdehyde (MDA) assay to measure the degree of protection against cell damage. In addition, this study used quantitative real-time polymerase chain reaction (qRT-PCR) to measure the expression of repaired genes from cell damage. Results: Sinapic acid protects cells from UVB-induced cytotoxicity and reduces ROS generation by UVB. This study showed that sinapic acid reduced the generation of tailed DNA, CPD, and lipid peroxidation, which are the indicators of DNA damage. Depending on the increase in the concentration of sinapic acid, the gene expressions of XPC and ERCC1 (repair factors for damaged DNA) increased. Conclusions: The findings of this study confirmed that sinapic acid is effective in removing ROS generated by UVB, reducing intracellular damage, and repairing damaged DNA in HaCaT. These results also showed that sinapic acid is effective in DNA damage repair, indicating its protective effect on HaCaT against UVB damage.

show abstract

Sinapic acid ameliorate cadmium-induced nephrotoxicity: In vivo possible involvement of oxidative stress, apoptosis, and inflammation via NF-κB downregulation

Cited by 95 publications

References 48 publications

The Effects of Sinapic Acid on the Development of Metabolic Disorders Induced by Estrogen Deficiency in Rats

The Effects of Sinapic Acid on the Development of Metabolic Disorders Induced by Estrogen Deficiency in Rats

Antihyperuricemic effect of dietary polyphenol sinapic acid commonly present in various edible food plants

Cytoprotective effects of sinapic acid on human keratinocytes (HaCaT) against ultraviolet B

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