Sinapic acid and resveratrol alleviate oxidative stress with modulation of gut microbiota in high-fat diet-fed rats

Yang, Czau‐Siung; Deng, Qianchun; Xu, Jianing; Wang, Xu; Hu, Chao S.; Tang, Hu; Huang, Fenghong

doi:10.1016/j.foodres.2018.10.003

Cited by 135 publications

(87 citation statements)

References 61 publications

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“…So far, data on the effect of SiA on the intestinal microbiota have been scarce. In a recent study in male Wistar rats (30 weeks old) on an HFD (45% fat), 270 oral supplementation of SiA (200 mg kg −1 d −1 for 8 weeks) improved the diversity of gut microbiota and enhanced the proportion of Blautia and Dorea in the Lachaospiraceae family, while reducing the growth of Bacteroides and Desulfovibrionaceae -which are usually associated with inflammation and disease in humans. 271,272 In the above study, SiA was shown to have a strong effect on relieving oxidative stress in the liver and colon.…”

Section: Sinapic Acidmentioning

confidence: 99%

“…271,272 In the above study, SiA was shown to have a strong effect on relieving oxidative stress in the liver and colon. 270 HFDs usually increase the proportion of lipopolysaccharidecontaining microbiota (Gram-negative bacteria) in the gut, while decreasing the number of bifidobacteria (Gram-positive bacteria). 273 This dysbiosis causes a two-to threefold increase in plasma lipopolysaccharide (metabolic endotoxemia), which triggers body weight gain and diabetes 273 by increasing intestinal permeability.…”

Section: Sinapic Acidmentioning

confidence: 99%

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Hydroxycinnamic acids and human health: recent advances

2019

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There is an urgent need to improve human diet globally. Compelling evidence gathered over the past several decades suggests that a suboptimal diet is associated with many chronic diseases and may be responsible for more deaths than any other risks worldwide. The main components in our diet that need higher intake are whole grains, fruit and vegetables, and nuts and seeds; all of these are important sources of dietary fiber and polyphenols. The health benefits of dietary fiber and polyphenols are also supported by several decades of valuable research. However, the conclusions drawn from interventional human trials are not straightforward and the action mechanisms in improving human health are not fully understood. Moreover, there is a great inter‐individual variation caused by different individual capabilities of processing, absorbing and using these compounds effectively. Data on the bioavailability and bioefficacy of hydroxycinnamic acids (HCAs) are limited when compared to other classes of polyphenols (e.g. anthocyanins). This review aims to summarize the latest research advances related to HCA bioavailability and their biological effects revealed by epidemiological data, pre‐clinical and clinical studies. Moreover, we aim to review the effects of HCAs on gut microbiota diversity and function and its respective influence on host health. © 2019 Society of Chemical Industry

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Section: Sinapic Acidmentioning

confidence: 99%

Section: Sinapic Acidmentioning

confidence: 99%

Hydroxycinnamic acids and human health: recent advances

2019

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“…Enterococcus faecalis is associated with high levels of extracellular superoxide [166]. A recent study suggests that resveratrol supplementation can increase the population of butyrate producer Blautia and Dorea in the Lachnospiraceae family [167]. Resveratrol also increases the expression of fasting-induced adipose factor (Fiaf), a key gene for triglycerides deposition, which may be associated with the its prebiotic effect on gut microbiota [165].…”

Section: The Interaction Between Resveratrol Gut Microbiota and Artementioning

confidence: 99%

Resveratrol and the Interaction between Gut Microbiota and Arterial Remodelling

Man

Xia

2020

Nutrients

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Arterial remodelling refers to the alteration in the structure of blood vessel that contributes to the progression of hypertension and other cardiovascular complications. Arterial remodelling is orchestrated by the crosstalk between the endothelium and vascular smooth muscle cells (VSMC). Vascular inflammation participates in arterial remodelling. Resveratrol is a natural polyphenol that possesses anti-oxidant and anti-inflammatory properties and has beneficial effects in both the endothelium and VSMC. Resveratrol has been studied for the protective effects in arterial remodelling and gut microbiota, respectively. Gut microbiota plays a critical role in the immune system and inflammatory processes. Gut microbiota may also regulate vascular remodelling in cardiovascular complications via affecting endothelium function and VSMC proliferation. Currently, there is new evidence showing that gut microbiota regulate the proliferation of VSMC and the formation of neointimal hyperplasia in response to injury. The change in population of the gut microbiota, as well as their metabolites (e.g., short-chain fatty acids) could critically contribute to VSMC proliferation, cell cycle progression, and migration. Recent studies have provided strong evidence that correlate the effects of resveratrol in arterial remodelling and gut microbiota. This review aims to summarize recent findings on the resveratrol effects on cardiovascular complications focusing on arterial remodelling and discuss the possible interactions of resveratrol and the gut microbiota that modulate arterial remodelling.

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“…Research indicates a pro‐inflammatory alteration in gut microbiome in MS, and microbiota transplants from MS patients into germ‐free mice have been shown to result in increased severity in EAE symptoms and reduced proportions of anti‐inflammatory IL‐10+Tregs . Notably, inflammation and OS play an important role in the pathological processes involving a disrupted gut microbiome and several studies have shown that antioxidants can prevent or reverse dysbiosis …”

Section: Elucidation Of the Role Of Oxidative Stress (Os) And Mitochomentioning

confidence: 99%

“…154 Notably, inflammation and OS play an important role in the pathological processes involving a disrupted gut microbiome 155 and several studies have shown that antioxidants can prevent or reverse dysbiosis. [156][157][158][159][160]…”

Section: Gut Bacteriamentioning

confidence: 99%

On elucidation of the role of mitochondria dysfunction and oxidative stress in multiple sclerosis

Tobore

2019

Neurology & Clinical Neurosc

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Multiple sclerosis (MS) is a complex human neurodegenerative dysimmune disease of the central nervous system (CNS) which is characterized by chronic inflammation, demyelination, loss of blood‐brain barrier (BBB) integrity, neuronal loss, reactive astrogliosis, and oligodendrocyte depletion. It can result in physical disability and severe neurological and cognitive deficits. Research indicates that MS prevalence has significantly increased in many regions around the world since 1990. The specific elements that trigger MS remain unknown. In this paper, the critical role played by mitochondria dysfunction and oxidative stress in MS pathogenesis, progression, and clinical symptoms are elucidated. Their interactions with the key factors in the disease, as well as treatment strategies, are discussed.

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Sinapic acid and resveratrol alleviate oxidative stress with modulation of gut microbiota in high-fat diet-fed rats

Cited by 135 publications

References 61 publications

Hydroxycinnamic acids and human health: recent advances

Hydroxycinnamic acids and human health: recent advances

Resveratrol and the Interaction between Gut Microbiota and Arterial Remodelling

On elucidation of the role of mitochondria dysfunction and oxidative stress in multiple sclerosis

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