Sinapine, but not sinapic acid, counteracts mitochondrial oxidative stress in cardiomyocytes

Boulghobra, Doria; Grillet, Pierre-Edouard; Laguerre, Mickaël; Tenon, Mathieu; Fauconnier, Jérémy; Fança-Berthon, Pascale; Reboul, Cyril; Cazorla, Olivier

doi:10.1016/j.redox.2020.101554

Cited by 43 publications

(24 citation statements)

References 44 publications

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“…Previous studies proved that ST has a satisfactory antihypertensive effect ( Huang et al, 2011 ; Boulghobra et al, 2020 ), and we also found that ST reduced inflammatory injury to a certain extent ( Li et al, 2017 ). We chose the aorta from WKY rats and SHRs to extract vascular endothelial cells for subsequent experiments, and after ST intervention in SHRs, the expression of NLRP3 and caspase-1 decreased with the suppression of NLRP3 inflammasome activity.…”

Section: Discussionsupporting

confidence: 80%

Sinapine Thiocyanate Ameliorates Vascular Endothelial Dysfunction in Hypertension by Inhibiting Activation of the NLRP3 Inflammasome

Liu

Yin

et al. 2021

Front. Pharmacol.

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The increase of blood pressure is accompanied by the changes in the morphology and function of vascular endothelial cells. Vascular endothelial injury and hypertension actually interact as both cause and effect. A large number of studies have proved that inflammation plays a significant role in the occurrence and development of hypertension, but the potential mechanism between inflammation and hypertensive endothelial injury is still ambiguous. The purpose of this study was to explore the association between the activation of NLRP3 inflammasome and hypertensive endothelial damage, and to demonstrate the protective effect of sinapine thiocyanate (ST) on endothelia in hypertension. The expression of NLRP3 gene was silenced by tail vein injection of adeno-associated virus (AAVs) in spontaneously hypertensive rats (SHRs), indicating that activation of NLRP3 inflammasome accelerated hypertensive endothelial injury. ST not only protected vascular endothelial function in SHRs by inhibiting the activation of NLRP3 inflammasome and the expression of related inflammatory mediators, but also improved AngII-induced huvec injury. In summary, our results show that alleviative NLRP3 inflammasome activation attenuates hypertensive endothelial damage and ST ameliorates vascular endothelial dysfunction in hypertension via inhibiting activation of the NLRP3 inflammasome.

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Section: Discussionsupporting

confidence: 80%

Sinapine Thiocyanate Ameliorates Vascular Endothelial Dysfunction in Hypertension by Inhibiting Activation of the NLRP3 Inflammasome

Liu

Yin

et al. 2021

Front. Pharmacol.

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“…Red cabbage microgreens were noted to be both unique in containing sinapine (hydrocinnamic acid/phenolic acid), and to contain higher concentrations of it than mature red cabbage. Sinapine has been reported to modulate circulating lipids, inflammation, and the gut microbiota in mice fed a high-fat diet ( 38 ), and to attenuate mitochondrial oxidative stress in cardiomyocytes ( 39 ), suggesting the potential of red cabbage microgreens to exert cardioprotective effects. Indeed, Huang et al ( 40 ) demonstrated that red cabbage microgreens modulated circulating and liver lipids, and inflammatory cytokines in mice fed a high-fat diet.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Evaluation of Metabolites and Minerals in 6 Microgreen Species and the Influence of Maturity

Johnson

Prenni

Heuberger

et al. 2021

Current Developments in Nutrition

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Background Microgreens are the young leafy greens of many vegetables, herbs, grains, and flowers with potential to promote human health and sustainably diversify the global food system. For successful further integration into the global food system and evaluation of their health impacts, it is critical to elucidate and optimize their nutritional quality. Objective We aimed to comprehensively evaluate the metabolite and mineral contents of six microgreens species, and the influence of maturity on their contents. Methods Plant species evaluated were from the Brassicaceae (arugula, broccoli, and red cabbage), Amaranthaceae (red beet and red amaranth), and Fabaceae (pea) plant families. Non-targeted metabolomics and ionomics analyses were performed to examine the metabolites and minerals, respectively, in each microgreen species and its mature counterpart. Results Non-targeted metabolomics analysis detected 3,321 compounds, 1,263 of which were annotated and included nutrients and bioactive compounds. Ionomics analysis detected and quantified 26 minerals including macrominerals, trace minerals, ultratrace minerals, and other metals. Principal component analysis indicated microgreens have distinct metabolite and mineral profiles compared with one another and with their mature counterparts. Several compounds were higher (p < 0.05; fold change ≥ 2) in microgreens compared to their mature counterpart, while some were unchanged or lower. In many cases, compounds that were higher in microgreens compared to the mature counterpart were also unique to that microgreen species. Conclusions These data provide evidence for the nutritional quality of microgreens, and can inform future research and development aimed at characterizing and optimizing microgreen nutritional quality and health impacts.

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“…These compounds have been detected mainly in the methanolic GP extracts and these chemical structures exert strong antioxidant properties [ 53 ]. Indeed, sinapine can counter reactive oxygen species (ROS) by interacting with mitochondrial systems, as observed by several authors in cardiomyocyte cultures [ 54 ]. Interesting data have been collected on cirsimaritin, a dimethoxy flavone present in some plants.…”

Section: Resultsmentioning

confidence: 99%

Protective Effects of Gynostemma pentaphyllum (var. Ginpent) against Lipopolysaccharide-Induced Inflammation and Motor Alteration in Mice

et al. 2021

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Gynostemma pentaphyllum (var. Ginpent) (GP) is a variety of Cucurbit with anti-inflammatory and antioxidant effects in patients. In this manuscript, the main components present in the dry extract of GP have been identified using Ultra High Performance Liquid Chromatography quadrupole-time-of-flight mass spectrometry (UHPLC/Q-TOF-MS). In addition, the anti-inflammatory action of GP was evaluated in animal models with acute peripheral inflammation and motor alteration induced by lipopolysaccharide. The results showed that GP dry extract is rich in secondary metabolites with potential antioxidant and anti-inflammatory properties. We found that the treatment with GP induced a recovery of motor function measured with the rotarod test and pole test, and a reduction in inflammatory cytokines such as interleukin-1β and interleukin-6 measured with the ELISA test. The data collected in this study on the effects of GP in in vivo models may help integrate the therapeutic strategies of inflammatory-based disorders.

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Sinapine, but not sinapic acid, counteracts mitochondrial oxidative stress in cardiomyocytes

Cited by 43 publications

References 44 publications

Sinapine Thiocyanate Ameliorates Vascular Endothelial Dysfunction in Hypertension by Inhibiting Activation of the NLRP3 Inflammasome

Sinapine Thiocyanate Ameliorates Vascular Endothelial Dysfunction in Hypertension by Inhibiting Activation of the NLRP3 Inflammasome

Comprehensive Evaluation of Metabolites and Minerals in 6 Microgreen Species and the Influence of Maturity

Protective Effects of Gynostemma pentaphyllum (var. Ginpent) against Lipopolysaccharide-Induced Inflammation and Motor Alteration in Mice

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