Síndrome antissintetase: anti-PL-7, anti-PL-12 e anti-EJ

Souza, Fernando Henrique Carlos de; Cruellas, Marcela Gran Pina; Levy‐Neto, Maurício; Shinjo, Samuel Katsuyuki

doi:10.1590/s0482-50042013000400007

Cited by 14 publications

(3 citation statements)

References 28 publications

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“…Regarding interstitial disease, Henrique et al [ 21 ], in a study carried out in Brazil, found a strong association between the presence of anti-PL7 (90%) or anti-PL12 (100%) and the development of interstitial disease. Although our patient 3 had a disease onset with the development of nonspecific interstitial pneumonitis, patient 1 had no compromising clinical or imaging findings, leading us to think that the disease may be different in the Colombian population than in others.…”

Section: Discussionmentioning

confidence: 99%

“…Although our patient 3 had a disease onset with the development of nonspecific interstitial pneumonitis, patient 1 had no compromising clinical or imaging findings, leading us to think that the disease may be different in the Colombian population than in others. Latin American citizens or, failing that, the myopathy panel could be a factor for an early diagnosis of the disease [ 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

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Unusual presentation of antisynthetase syndrome: a case series and review of the literature

Estrada-Maya,

de los Ángeles Cuellar,

Vargas

et al. 2023

J Med Case Reports

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Background Antisynthetase syndrome is an inflammatory myopathy that is characterized by the presence of anti-aminoacyl-tRNA synthetase antibodies. Only 30% of those who suffer from the disease can be identified. We present three Hispanic cases of antisynthetase syndrome with unusual clinical pictures were extended myositis panel results enable disease diagnosis and treatment. Case presentation A 57-year-old Hispanic/Latino female with an erythematous scaly plaque, unresolved fever and non-immune haemolytic anaemia in whom inpatient work-up for fever of unknown origin was positive for anti-PL12 positive myositis extended panel. A 72-year-old Hispanic/Latino male with amyopathic weakness syndrome and mechanic hands in whom impatient work-up was relevant for proximal muscle uptake and anti-PM75 and AntiPL-12 myositis extended panel. And a 67-year-old Hispanic/Latino male with progressive interstitial lung disease and unresolved fever ended in myositis extended panel positive for antiPL-7. After systemic immunosuppressor treatment, patients had favourable clinical and paraclinical responses during outpatient follow-up. Conclusions The high variability of the antisynthetase syndrome in these cases demonstrates the importance of identification through an expanded panel and highlights the probability that this is a variable disease and that we need to include emerging molecular tests to promote the timely treatment of patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Unusual presentation of antisynthetase syndrome: a case series and review of the literature

Estrada-Maya,

de los Ángeles Cuellar,

Vargas

et al. 2023

J Med Case Reports

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“…In addition, the anti-EJ type of antisynthetase syndrome primarily affects white women and has a high recurrence rate. Results of a retrospective cohort study showed that half of all patients with anti-EJ antibodies were diagnosed with classic dermatomyositis and clinically amyopathic dermatomyositis [13]. …”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Necrotizing Myopathy and Fibrinous and Organizing Pneumonia with Anti-EJ Antisynthetase Syndrome and SSA Antibodies

et al. 2017

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Objective:Rare co-existance of disease or pathology Background:Idiopathic inflammatory myopathies are autoimmune disorders that can involve the skin, joints, muscles, and lungs. The most common of these disorders are dermatomyositis, polymyositis, overlap syndrome, and inclusion body myositis. Necrotizing autoimmune myopathy is an idiopathic inflammatory myopathy that is rarely associated with Sjögren's syndrome. The most common lung findings associated with anti-EJ antisynthetase syndrome are nonspecific interstitial pneumonia and usual interstitial pneumonia; this condition is rarely associated with fibrinous and organizing pneumonia. Case Report:Here, we present a rare case of necrotizing myopathy and fibrinous and organizing pneumonia in a 34-yearold African American man with Sjögren's syndrome and anti-EJ antibodies. The patient's presenting symptoms were cough and proximal muscle weakness of the extremities. He had elevated serum creatine kinase level, aldolase level, and erythrocyte sedimentation rate. Myositis panel was positive for anti-EJ antibodies. Chest radiography was consistent with bilateral interstitial infiltrates. CT chest showed patchy bilateral infiltrates. Quadriceps muscle biopsy revealed widespread necrotic fibers and lung biopsy showed fibrinous and organizing pneumonia. The patient responded well to immunoglobulin therapy, mycophenolate, and prednisone, which resulted in complete resolution of bilateral infiltrates and improved muscle pain and weakness. Conclusions:Myopathies are characterized by myalgia and muscle weakness due to muscle fiber dysfunction and are associated with autoimmune diseases. Histopathological features may differ in idiopathic inflammatory myopathies. It is important to recognize the rare association of anti-EJ autoantibodies with necrotizing myopathy and interstitial lung disease, which responds well to methylprednisolone and intravenous immunoglobulin.

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Mit Schluckstörungen assoziierte Erkrankungen

Prosiegel¹,

Weber²

2018

Dysphagie

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Síndrome antissintetase: anti-PL-7, anti-PL-12 e anti-EJ

Cited by 14 publications

References 28 publications

Unusual presentation of antisynthetase syndrome: a case series and review of the literature

Unusual presentation of antisynthetase syndrome: a case series and review of the literature

A Rare Case of Necrotizing Myopathy and Fibrinous and Organizing Pneumonia with Anti-EJ Antisynthetase Syndrome and SSA Antibodies

Mit Schluckstörungen assoziierte Erkrankungen

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