This article addresses the phenomenon of burnout in the healthcare sector in the city of Guayaquil, Ecuador, exploring the complex interactions between work challenges and the socio-economic environment. From the local context to specific manifestations and underlying causes, this analysis seeks to provide an understanding of a critical problem affecting healthcare professionals, demanding innovative strategies for prevention and mitigation. The methodology employed is quantitative in nature, utilizing an instrument based primarily on the Maslach Burnout Inventory, comprising three dimensions: emotional exhaustion, depersonalization, and personal accomplishment. Three groups were defined for analysis: no burnout, mild/moderate burnout, and severe burnout. 33.65% of healthcare professionals do not exhibit high values in burnout dimensions, while 13.94% exhibit severe burnout. Statistically significant relationships are found between the presence of the syndrome and most demographic variables. It is concluded that there is an impact on the quality of life of healthcare professionals, which affects patient care in both public and private institutions. Implementation of intervention programs is recommended to mitigate the effects of burnout on the physical and mental well-being of healthcare professionals.