2006
DOI: 10.1157/13090900
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Síndrome de Crigler-Najjar: diagnóstico y tratamiento

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Cited by 12 publications
(6 citation statements)
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“…Despite the severity of the disease, there are options for treatment of CNS [23][24][25] which include: -Phototherapy: acts by converting a portion of bilirubin in a hydrophilic isomer, which can be excreted in the bile without the need for further conjugation in the liver. This technique involves exposure to light and heat 10-12 h per day [26] .…”
Section: Discussionmentioning
confidence: 99%
“…Despite the severity of the disease, there are options for treatment of CNS [23][24][25] which include: -Phototherapy: acts by converting a portion of bilirubin in a hydrophilic isomer, which can be excreted in the bile without the need for further conjugation in the liver. This technique involves exposure to light and heat 10-12 h per day [26] .…”
Section: Discussionmentioning
confidence: 99%
“…A fototerapia pode ser associada com quelantes biliares (carbonato de cálcio e colestiramina) e plasmaferese. 4,8,9 O objetivo é manter os níveis de bilirrubina indireta abaixo de 20 mg/dL. O único tratamento curativo é o transplante hepático.…”
Section: -46unclassified
“…O uso do fenobarbital reduz os níveis de bilirrubina indireta em 25% e também permite a distinção entre o tipo 1 e o tipo 2, uma vez que no primeiro não há qualquer resposta à sua administração. 4,8 A SCN tipo 2 tem uma evolução clínica mais benigna e é raro o desenvolvimento de kernicterus. Quando este ocorre, geralmente os doentes sofreram algum tipo de intercorrência, como infeção, ou outro tipo de stress.…”
unclassified
“…218800, 606785) type I and type II are inherited as autosomal recessive conditions that is resulted from mutations in the UGT1A1 gene ( UGT1A1 ; MIM nos. 191740) [1–4]. Type I is characterized by almost complete absence of UGT1A1 enzyme activity, and these patients are refractory to phenobarbital treatment, while type II is a less severe form of deficiency [5, 6].…”
Section: Introductionmentioning
confidence: 99%