Síndrome de Lyell por imipramina: relato de caso

Dias, Vanderson Glerian; Aguni, Joran Seiko; Bezzon, Ana Karina Teixeira

doi:10.1590/s0004-27492004000600019

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…Also called a mixed reuptake inhibitor, imipramine, which equally inhibits both norepinephrine and the serotonin reuptake, has been used in various forms of depression. 5 During organogenesis, medication can be teratogenic, thereby causing congenital malformations and serious damages that may lead to abortion. Although, if used during the second and third trimesters, medication is no longer able to produce significant malformations, it can affect the fetus's functional development and growth.…”

Section: Introductionmentioning

confidence: 99%

Effects of fluoxetine and imipramine in rat fetuses treated during a critical gestational period: a macro and microscopic study

Swerts

Costa

Esteves

et al. 2009

Rev. Bras. Psiquiatr.

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OBJECTIVE: To evaluate morphological alterations in rat fetuses treated with fluoxetine and imipramine during the "critical" period of gestation. METHOD: Fifteen female rats were separated into three groups (n = 5) and treated with 10 mg/kg/day of test substances on the ninth, tenth and eleventh day of pregnancy: G1, fluoxetine; G2, imipramine hydrochloride; G3 (control), saline. On day 21, cesarean sections were performed to release the fetuses, whose bodies were weighed and macroscopically analyzed. The placenta was also weighed. The fetuses were then fixed and their encephala removed and weighed. Sections of the frontal lobe were taken for histological neuron counting. RESULTS: G1 and G2 showed the highest fetal body weight. Placental weight showed statistical differences (p < 0.01): G1 weighed more than G2 and G3. Otherwise, G2 exhibited the highest encephalon weight, statistically differing from G3 (control) and fluoxetine-treated G1 (p < 0.01). However, G1 did not statistically (p > 0.01) differ from the control group. G3 showed the highest number of neurons per area when compared to G1 and G2 (p < 0.01). CONCLUSION: The use of antidepressants in rats caused an increase in fetal weight and a decrease in the number of fetal frontal lobe neurons, thus suggesting that the use of antidepressants by pregnant women can induce depression in fetuses due to alterations in their neural development.

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Section: Introductionmentioning

confidence: 99%

Effects of fluoxetine and imipramine in rat fetuses treated during a critical gestational period: a macro and microscopic study

Swerts

Costa

Esteves

et al. 2009

Rev. Bras. Psiquiatr.

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Chronic administration of harmine elicits antidepressant-like effects and increases BDNF levels in rat hippocampus

et al. 2010

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A growing body of evidence has pointed to the β-carboline harmine as a potential therapeutic target for the treatment of major depression. The present study was aimed to evaluate behavioural and molecular effects of the chronic treatment with harmine and imipramine in rats. To this aim, rats were treated for 14 days once a day with harmine (5, 10 and 15 mg/kg) and imipramine (10, 20 and 30 mg/kg) and then subjected to the forced swimming and open-field tests. Harmine and imipramine, at all doses tested, reduced immobility time of rats compared with the saline group. Imipramine increased the swimming time at 20 and 30 mg/kg and harmine increased swimming time at all doses. The climbing time increased in rats treated with imipramine (10 and 30 mg/kg) and harmine (5 and 10 mg/kg), without affecting spontaneous locomotor activity. Brain-derived neurotrophic factor (BDNF) hippocampal levels were assessed in imipramine and harmine-treated rats by ELISA sandwich assay. Interestingly, chronic administration of harmine at the higher doses (10 and 15 mg/kg), but not imipramine, increased BDNF protein levels in rat hippocampus. Finally, these findings further support the hypothesis that harmine could bring about behavior and molecular effects, similar to antidepressants drugs.

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Síndrome de Lyell por imipramina: relato de caso

Cited by 2 publications

References 14 publications

Effects of fluoxetine and imipramine in rat fetuses treated during a critical gestational period: a macro and microscopic study

Effects of fluoxetine and imipramine in rat fetuses treated during a critical gestational period: a macro and microscopic study

Chronic administration of harmine elicits antidepressant-like effects and increases BDNF levels in rat hippocampus

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