Síndrome de opsoclonia-mioclonia-ataxia em paciente com AIDS

Vale, Thiago Cardoso; Silva, Rodrigo Alencar e; Cunningham, Mauro César Quintão; Maia, Débora Palma; Camargos, Sarah Teixeira; Cardoso, Francisco

doi:10.1590/s1679-45082013000400023

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…OMA is characterized by continuous multidirectional saccadic eye movements accompanied by generalized myoclonus and, less frequently, cerebellar ataxia, postural tremor, encephalopathy and behavioural disturbances. It is also known as ‘dancing eye and dancing feet syndrome’ [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

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Opsoclonus–myoclonus–ataxia syndrome in an HIV-infected child

2016

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Opsoclonus–myoclonus–ataxia (OMA) syndrome typically presents with chaotic eye movements and myoclonus with some patients exhibiting ataxia and behavioural disturbances. The pathogenesis may be inflammatory with an infectious or paraneoplastic trigger. We present a 13-year-old HIV-infected girl who was initially started on highly active antiretroviral therapy (HAART) in March 2013 with a CD4 count of 79 cells/cumm. Initially, the patient did not comply with treatment, resulting in a CD4+ count of 77 cells/mm3 in November 2015 and prompting a new HAART scheme comprising lamivudine, tenofovir and ritonavir-boosted atazanavir. Shortly after starting this scheme, she developed OMA syndrome in January 2016. She was treated with intravenous immunoglobulin and methylprednisolone followed by oral steroids along with oral clonazepam and gradually recovered. We suggest immune reconstitution inflammatory syndrome as a possible aetiology of OMA in HIV-infected children.

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Section: Discussionmentioning

confidence: 99%

“…OMA may improve spontaneously when mild, or require immune therapy when symptoms are persistent [ 2 ]. Therapies used for OMA include IVIGs, prednisolone and anti-epileptic γ-aminobutyric acid agonist gabapentine.…”

Section: Discussionmentioning

confidence: 99%

Opsoclonus–myoclonus–ataxia syndrome in an HIV-infected child

2016

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HIV-associated opsoclonus-myoclonus-ataxia syndrome: early infection, immune reconstitution syndrome or secondary to other diseases? Case report and literature review

et al. 2017

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Opsoclonus-myoclonus-ataxia (OMA) syndrome is a debilitating autoimmune neurological disorder. Post-infectious opsoclonus-myoclonus-ataxia syndrome has been described with varying bacterial, spirochetal, and viral infections including several patients with HIV. However, specific immunopathological mechanisms that may lead to opsoclonus-myoclonus in HIV-positive patients are unknown.We report a case of HIV-associated opsoclonus-myoclonus and early HIV infection. A review of published literature shows opsoclonus-myoclonus can occur during early infection, in immune reconstitution syndrome or in association with other infections, especially tuberculosis.

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