Síndrome hemolítico-urémico y Streptococo pneumoniae: Report of one case

H, Enrique Reynolds; R, Mauricio Espinoza; F, Gustavo Mönckeberg; S, Jerónimo Graf

doi:10.4067/s0034-98872002000600012

Cited by 5 publications

(1 citation statement)

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“…On the other hand, some studies suggest that some CAF subpopulations inhibit tumor progression: Depletion of α-smooth muscle actin (SMA) + CAFs accelerates tumor growth in a pancreatic cancer mouse model (Özdemir et al 2014). IL-4 receptorexpressing tumor stromal fibroblasts reportedly facilitate tumor rejection in a murine syngeneic tumor model based on a mouse plasmacytoma cell line (Reynolds et al 2002). Moreover, PDGFRα + CAFs are suggested to play tumorinhibitory roles in colon cancer (Koliaraki et al 2017).…”

Section: Discussionmentioning

confidence: 99%

Dual functions of angiopoietin-like protein 2 signaling in tumor progression and anti-tumor immunity

et al. 2019

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Angiopoietin-like protein 2 (ANGPTL2) is a secreted glycoprotein homologous to angiopoietins. Previous studies suggest that tumor cell-derived ANGPTL2 has tumor-promoting function. Here, we conducted mechanistic analysis comparing ANGPTL2 function in cancer progression in a murine syngeneic model of melanoma and a mouse model of translocation renal cell carcinoma (tRCC). ANGPTL2 deficiency in tumor cells slowed tRCC progression, supporting a tumor-promoting role. However, systemic ablation of ANGPTL2 accelerated tRCC progression, supporting a tumor-suppressing role. The syngeneic model also demonstrated a tumor-suppressing role of ANGPTL2 in host tumor microenvironmental cells. Furthermore, the syngeneic model showed that PDGFRα+ fibroblasts in the tumor microenvironment express abundant ANGPTL2 and contribute to tumor suppression. Moreover, host ANGPTL2 facilitates CD8+ T-cell cross-priming and enhances anti-tumor immune responses. Importantly, ANGPTL2 activates dendritic cells through PIR-B–NOTCH signaling and enhances tumor vaccine efficacy. Our study provides strong evidence that ANGPTL2 can function in either tumor promotion or suppression, depending on what cell type it is expressed in.

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Section: Discussionmentioning

confidence: 99%

Dual functions of angiopoietin-like protein 2 signaling in tumor progression and anti-tumor immunity

et al. 2019

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Pneumococcal hemolytic uremic syndrome and steroid resistant nephrotic syndrome

et al. 2016

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Pneumococcal-associated hemolytic uremic syndrome (pHUS) is a rare but severe complication of invasive Streptococcus pneumoniae infection. We report the case of a 12-year-old female with steroid-resistant nephrotic syndrome treated with adrenocorticotrophic hormone (H.P. Acthar® Gel), who developed pneumococcal pneumonia and subsequent pHUS. While nephrotic syndrome is a well-known risk factor for invasive pneumococcal disease, this is the first reported case of pHUS in an adolescent patient with nephrotic syndrome, and reveals novel challenges in the diagnosis, treatment and potential prevention of this complication.

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