Síndrome nefrótico secundario a preeclampsia: presentación, manejo y evolución clínica observados en 5 años de experiencia

Ghelfi, A.M.; Garavelli, Florencia; Meres, B; Dipaolo, F R; Lassus, M.; Pahud, A L; Vazquez, M; Kilstein, Jorge Guillermo; D'Andrea, R F Mamprin

doi:10.1016/j.hipert.2022.05.008

Cited by 2 publications

(3 citation statements)

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“…[ 14 , 15 ]. Maternal outcomes in PE-induced NS have been studied previously; the results were promising, and no deaths were observed [ 16 , 17 ]. This is consistent with the results obtained in this study and may be related to the fact that the mother was protected from the adverse outcomes by the aggressive medical care she received.…”

Section: Discussionmentioning

confidence: 99%

“…Some womenwith NS demonstrate no evidence of kidney dysfunction. Studies have shown that women with normal NS pregnancies who do not have significant hypertension or renal insufficiency have better maternal and foetal outcomes [ 5 ]. Preeclampsia(PE), a common condition in pregnancy belonging to the "grand mal" group of obstetric syndromes, affects approximately 4.6% of all pregnancies worldwide [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, early prevention and management of maternal preeclampsia are essential for both the mother and foetus. Because of the similarity of symptoms to NS, the diagnosis and prevention of both are often closely linked [ 5 , 12 , 13 ]. Studies on the pregnancy outcomes of NS induced by PE during pregnancy are clear; however, few studies have examined the outcomes of PE during pregnancy in people with NS.…”

Section: Introductionmentioning

confidence: 99%

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A study of adverse maternal-foetal outcomes in nephrotic syndrome combined with preeclampsia

Li,

Zhang,

et al. 2023

BMC Pregnancy Childbirth

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Background Although the majority of pregnancies with preeclampsia are characterised by elevated blood pressure, preeclampsia is often associated with nephrotic syndrome with similar symptoms such as high proteinuria and bilateral lower limb oedema. In this study, we compared the maternal–foetal outcomes of pregnant women with preeclampsia in a population with nephrotic syndrome and explored the factors that contribute to the corresponding outcomes and disease development. Methods A total of 90 pregnant women were included in this study, of whom 30 had nephrotic syndrome and were diagnosed with preeclampsia during pregnancy, and 60 had nephrotic syndrome alone. Descriptive statistical analyses of baseline data were performed to analyse the effect of combined preeclampsia on maternal and foetal pregnancy outcomes using unadjusted and adjusted logistic regression models. Results In this study, the baseline data of the two study populations demonstrated no differences except for the history of caesarean section and 24-h proteinuria results, which were significantly different (P < 0.05). The risk of preterm birth in the nephrotic syndrome with preeclampsia group was 8.25 (95% CI:3.041–22.084 P < 0.05); for a low birth weight, the risk was 6.00 (95% CI:2.302–15.638 P < 0.05); for foetal distress,the risk was 5.667 (95% CI:2.070–15.514 P < 0.05); and the risk of foetal birth restriction was 7.429 (95% CI: 2.642–20.885 P < 0.05). A risk-based analysis of adverse maternal outcomes yielded a risk of miscarriage of 2.200 (95% CI: 0.584–8.291; P > 0.05). After adjusting the model for each outcome, significant risks of preterm labour, foetal birth restriction, and low birth weight were revealed (P < 0.05). Conclusion Combined preeclampsia has a significantly higher risk of adverse pregnancy outcomes for the foetus.Therefore, the prevention and control of eclampsia in pregnant women should be improved to ensure maternal and neonatal health.

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