2021
DOI: 10.1002/adhm.202002287
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Single Administration of a Biodegradable, Separable Microneedle Can Substitute for Repeated Application of Eyedrops in the Treatment of Infectious Keratitis

Abstract: Infectious keratitis is mainly treated with topical antibiotics. To achieve and maintain the required therapeutic concentration in the cornea where the tear fluid continuously rinses the surface, the antibiotics must be frequently applied, even while the patient is sleeping, and oral medication is sometimes required. However, the inevitably poor compliance and avascular nature of the cornea decrease drug bioavailability. In this study, a single microneedle (MN) is injected into the cornea to substitute for the… Show more

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Cited by 10 publications
(5 citation statements)
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“… [ 137 ] PLGA, SU8 resin Arrays: 1 needle Height: 150 ​μm Shape: Tapered Strength: 00.3–0.4 ​N/neelde Antibiotics The drug-tip is separated from base and released drugs after the hydrolysis of PLGA occurred in cornea. [ 143 ] Poly(D, l -lactide), HA Arrays: 20 ​× ​20 Height: 390 ​μm Shape: pyramidal Strength: Fluconazole Penetrating the corneal epithelial layer reversibly; Increasing the residence time of drug in the conjunctival sac [ 144 ] …”
Section: Mns For Istrmentioning
confidence: 99%
See 1 more Smart Citation
“… [ 137 ] PLGA, SU8 resin Arrays: 1 needle Height: 150 ​μm Shape: Tapered Strength: 00.3–0.4 ​N/neelde Antibiotics The drug-tip is separated from base and released drugs after the hydrolysis of PLGA occurred in cornea. [ 143 ] Poly(D, l -lactide), HA Arrays: 20 ​× ​20 Height: 390 ​μm Shape: pyramidal Strength: Fluconazole Penetrating the corneal epithelial layer reversibly; Increasing the residence time of drug in the conjunctival sac [ 144 ] …”
Section: Mns For Istrmentioning
confidence: 99%
“…Keratitis caused by bacterial or fungal infections is one of the leading causes of corneal clouding and is the fourth leading cause of blindness worldwide [ [139] , [140] , [141] , [142] ]. Antifungal drugs or antibiotic-loaded MNs have been shown to possess higher bioavailability and better therapeutic efficacy compared to eye drops [ 143 , 144 ]. To address bacterial drug resistance, Xu et al.…”
Section: Mns For Istrmentioning
confidence: 99%
“…Microneedles offer an attractive alternative to the repeated use of eye drops as a treatment for keratitis. Park et al compared the mechanical strength and release of three microneedles with different drug contents and they found that the optimized biodegradable microneedles demonstrated easy insertion into the cornea and sustained release of 12.5 ng drug within 3 d. [81] Figure 4. Positions and modes of action of the three types of microneedles: solid-coated microneedles, hollow microneedles, and dissolved microneedles from top to bottom.…”
Section: Keratitismentioning
confidence: 99%
“…While antibiotic eye drops are commonly employed, they suffer from limitations such as poor bioavailability and the potential to foster antibioticresistant strains of bacteria. [8] Recently, biomedical patches have been developed to incorporate antibacterial or bioactive materials for infected cornea utilizing various techniques such as hydrogel, [9][10][11][12] microneedle, [13,14] three-dimensional (3D) printing, [15,16] electrospinning, [17,18] and microfluidics. [19,20] However, these patches often fall short in multiple areas: they are typically mono-functional and possess inadequate mechanical strength and tissue adhesion.…”
Section: Introductionmentioning
confidence: 99%