Single and mixed exposure to cadmium and mercury in Drosophila melanogaster: Molecular responses and impact on post-embryonic development

Frat, Laëtitia; Chertemps, Thomas; Pesce, Elise; Bozzolan, Françoise; Dacher, Matthieu; Planelló, Rosario; Herrero, Óscar; Llorente, Lola; Moers, Didier; Siaussat, David

doi:10.1016/j.ecoenv.2021.112377

Cited by 21 publications

(8 citation statements)

References 39 publications

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“…The MtnB protein is particularly central in the non-essential metal response. MtnB mutations are lethal, or reduce survivability when combined with Cd or Pb toxicity, while mutations in the other Mtn genes have less pronounced effects [ 52 , 69 , 84 ], suggesting that, similar to the situation with the essential metals, MtnC and MtnD have smaller roles in the response to metal toxicity. Further, MtnA and MtnB are both upregulated by exposure to Hg toxicity [ 84 ].…”

Section: Metallothioneins In Drosophila Melanogastermentioning

confidence: 99%

“…MtnB mutations are lethal, or reduce survivability when combined with Cd or Pb toxicity, while mutations in the other Mtn genes have less pronounced effects [ 52 , 69 , 84 ], suggesting that, similar to the situation with the essential metals, MtnC and MtnD have smaller roles in the response to metal toxicity. Further, MtnA and MtnB are both upregulated by exposure to Hg toxicity [ 84 ]. Mtn expression is upregulated in response to Hg in mammals both directly and indirectly through other pathways depending on the tissue type [ 85 ], so it is possible that upregulation in D. melanogaster is also indirect.…”

Section: Metallothioneins In Drosophila Melanogastermentioning

confidence: 99%

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The Effects of Essential and Non-Essential Metal Toxicity in the Drosophila melanogaster Insect Model: A Review

Slobodian

Petahtegoose

Wallis

et al. 2021

Toxics

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The biological effects of environmental metal contamination are important issues in an industrialized, resource-dependent world. Different metals have different roles in biology and can be classified as essential if they are required by a living organism (e.g., as cofactors), or as non-essential metals if they are not. While essential metal ions have been well studied in many eukaryotic species, less is known about the effects of non-essential metals, even though essential and non-essential metals are often chemically similar and can bind to the same biological ligands. Insects are often exposed to a variety of contaminated environments and associated essential and non-essential metal toxicity, but many questions regarding their response to toxicity remain unanswered. Drosophila melanogaster is an excellent insect model species in which to study the effects of toxic metal due to the extensive experimental and genetic resources available for this species. Here, we review the current understanding of the impact of a suite of essential and non-essential metals (Cu, Fe, Zn, Hg, Pb, Cd, and Ni) on the D. melanogaster metal response system, highlighting the knowledge gaps between essential and non-essential metals in D. melanogaster. This review emphasizes the need to use multiple metals, multiple genetic backgrounds, and both sexes in future studies to help guide future research towards better understanding the effects of metal contamination in general.

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Section: Metallothioneins In Drosophila Melanogastermentioning

confidence: 99%

Section: Metallothioneins In Drosophila Melanogastermentioning

confidence: 99%

The Effects of Essential and Non-Essential Metal Toxicity in the Drosophila melanogaster Insect Model: A Review

Slobodian

Petahtegoose

Wallis

et al. 2021

Toxics

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“…However, dietary Cd inhibited the activities of GST, CarE and P450 in Helicoverpa armigera [ 51 ]. In addition, metallothioneins (Mtns) in insects were increased upon exposure to Cd, Pb, and Hg, respectively [ 55 , 56 ]. The detailed mechanisms involved in the responses of sweet potato weevil to Cd exposure are worthy of further study.…”

Section: Discussionmentioning

confidence: 99%

Changes in the Biology and Susceptibility of Weevil (Cylas formicarius) to the Insecticide Spinetoram as a Response to Cadmium Contamination

Xu,

Tang,

Liu

et al. 2024

Toxics

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The sweet potato weevil Cylas formicarius is a notorious underground pest in sweet potato (Ipomoea batatas L.). However, little is known about the effects of cadmium (Cd) stress on weevil biology and resistance to pesticides and biotic agents. Therefore, we fed sweet potato weevils with Cd-contaminated sweet potato and assessed adult food intake and survival and larval developmental duration and mortality rates, as well as resistance to the insecticide spinetoram and susceptibility to the entomopathogenic fungus Beauveria bassiana. With increasing Cd concentration, the number of adult weevil feeding holes, adult survival and life span, and larval developmental duration decreased significantly, whereas larval mortality rates increased significantly. However, at the lowest Cd concentration (30 mg/L), adult feeding was stimulated. Resistance of adult sweet potato weevils to spinetoram increased at low Cd concentration, whereas Cd contamination did not affect sensitivity to B. bassiana. Thus, Cd contamination affected sweet potato weevil biology and resistance, and further studies will investigate weevil Cd accumulation and detoxification mechanisms.

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“…Recent studies suggested that binary mixtures of heavy metals have inhibitory effects on organisms [5], demonstrating additive [49], synergistic [50] or antagonistic interactions [26,51]. Concurrent exposure to 0.5 mg/L mercury (Hg) and 0.2-2 mg/L Cd induced a delay of larval-pupal transitions in Drosophila melanogaster, confirming joint effects between Cd and Hg [50]. The silkworm (Bombyx mori) fed Pb and Cd mixtures had a larger body size than when fed Cd alone [52], showing an antagonistic response.…”

Section: Discussionmentioning

confidence: 99%

Complex Cd–Pb Multigenerational Exposure Improves the Growth and Food Utilization of the Cutworm Spodoptera litura

Zhang

Chen

et al. 2023

Agronomy

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Concurrent exposure to cadmium (Cd) and lead (Pb) is prevalent in the environment, but information on the long-term impacts of complex Cd–Pb exposure on herbivorous insects, especially at low doses, is scant. We studied the effects of complex Cd–Pb exposure (4.06 mg/kg Cd and 12.5 mg/kg Pb) on the growth and food utilization of the herbivorous insect Spodoptera litura for 10 continuous generations. Cd or Pb ingestion, excretion and accumulation by insect at the different developmental stages was determined for ten generations. The weighted scores calculated by the analytic hierarchy process (AHP) on the basis of the parameters of survival, growth and food utilization indicated that complex Cd–Pb exposure had positive impacts on the insects, regardless of generations. Compared with Cd (4.06 mg/kg Cd) and Pb (12.5 mg/kg Pb) alone, complex Cd–Pb exposure showed antagonistic interactions. After exposure to complex Cd–Pb, although larvae significantly increased heavy metal uptake along with the elevated ECD and ECI, insects enhanced heavy metal excretion via the feces and puparium; consequently, heavy metal accumulation in the insect body significantly decreased. With increasing generations, the positive impacts of complex Cd–Pb stress on insects became increasingly obvious, and the uptake of Cd or Pb decreased while the excretion of Cd or Pb increased, which demonstrated that insect tolerance to Cd–Pb exposure at low concentrations increased over generations.

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Single and mixed exposure to cadmium and mercury in Drosophila melanogaster: Molecular responses and impact on post-embryonic development

Cited by 21 publications

References 39 publications

The Effects of Essential and Non-Essential Metal Toxicity in the Drosophila melanogaster Insect Model: A Review

The Effects of Essential and Non-Essential Metal Toxicity in the Drosophila melanogaster Insect Model: A Review

Changes in the Biology and Susceptibility of Weevil (Cylas formicarius) to the Insecticide Spinetoram as a Response to Cadmium Contamination

Complex Cd–Pb Multigenerational Exposure Improves the Growth and Food Utilization of the Cutworm Spodoptera litura

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