1984
DOI: 10.1128/aac.26.1.69
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Single- and multiple-dose pharmacokinetics of pipemidic acid in normal human volunteers

Abstract: The pharmacokinetic profile of pipemidic acid was studied in two groups of young healthy volunteers by using a new, sensitive, high-pressure liquid chromatography procedure for quantitation of pipemidic acid in biological fluids. After oral or intravenous administration, the disposition of pipemidic acid may be described as a one-or a two-compartment open model, respectively. Oral bioavailability was 93.1 + 11% (mean ± standard error). After administration of a 100-mg tablet, 13.4 ± 2.7% was bound to serum pro… Show more

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Cited by 17 publications
(2 citation statements)
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“…The antibiotics shown in bold are reference antibiotics. Values were obtained from three independent experiments and expressed as mean ± SD (n = 9). a The values are derived from the literature 26–30 b Shown as residual viable cell percentage calculated from cell counting under a fluorescence microscope.…”
Section: Resultsmentioning
confidence: 99%
“…The antibiotics shown in bold are reference antibiotics. Values were obtained from three independent experiments and expressed as mean ± SD (n = 9). a The values are derived from the literature 26–30 b Shown as residual viable cell percentage calculated from cell counting under a fluorescence microscope.…”
Section: Resultsmentioning
confidence: 99%
“…a. The values are derived from the literature[32][33][34][35][36].241 b. Shown as residual viable cell percentage calculated from cell counting under a fluorescence microscope.…”
mentioning
confidence: 99%