Single anti-P ribosomal antibodies are not associated with lupus nephritis in patients suffering from active systemic lupus erythematosus

Quintana, Gerardo; Coral-Alvarado, Paola; Aroca, Gustavo; Patarroyo, Paúl Méndez; Chalem, Philippe; Gamarra, Antonio Iglesias; Ruiz, A.; Cervera, Ricard

doi:10.1016/j.autrev.2010.06.004

Cited by 18 publications

(11 citation statements)

References 39 publications

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“…The 64 eligible studies comprised 66 cohorts with a total of 13,080 SLE patients, of whom 12,542 (95.9%) were reported to be IIF‐ANA positive at various titers (range 76% to 100% calculated sensitivity, see Table ). A total of 7,539 subjects were included as a control population.…”

Section: Resultsmentioning

confidence: 99%

Performance of Antinuclear Antibodies for Classifying Systemic Lupus Erythematosus: A Systematic Literature Review and Meta‐Regression of Diagnostic Data

Leuchten

Hoyer

Brinks³

et al. 2018

Arthritis Care & Research

147

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Section: Resultsmentioning

confidence: 99%

Performance of Antinuclear Antibodies for Classifying Systemic Lupus Erythematosus: A Systematic Literature Review and Meta‐Regression of Diagnostic Data

Leuchten

Hoyer

Brinks³

et al. 2018

Arthritis Care & Research

147

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“…However, none of the studies that demonstrated no correlations addressed the issue of the combined occurrence of anti-P and anti-dsDNA and the possible correlation of nephritis with the presence of both autoantibodies. In this regard, there was no association between anti-P and lupus nephritis, but anti-P coexisting with anti-dsDNA was associated with lupus nephritis in a study with 389 Columbian patients with SLE [38].…”

Section: Anti-p and Renal Involvement In Sle (Lupus Nephritis)mentioning

confidence: 94%

“…Fine epitopes of ribosomal P proteins Anti-P are directed to 3 phosphoproteins (P0, P1, and P2), which are located on the larger 60S subunit of eukaryotic ribosomes, and have molecular weights of 38,19, and 17 kDa, respectively [1]. Anti-P have been shown to react a common linear determinant that is present in the carboxyl-terminal 22-amino-acid sequence ( Fig.…”

Section: Autoantibodies To Ribosomal P Proteins (Anti-p)mentioning

confidence: 98%

Anti-ribosomal P antibodies and lupus nephritis

Hirohata

2011

Clin Exp Nephrol

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Increasing attention has been paid to the relationship of autoantibodies to ribosomal P proteins (anti-P) with lupus nephritis. Several mechanisms of involvement of anti-P in lupus nephritis have been proposed, including cross-reactivity with anti-dsDNA and anti-endothelial cell antibodies (AECA). In addition, it is also suggested that anti-P might play a role in the development of lupus nephritis through induction of T helper 1 responses. Of note, recent studies have disclosed that the presence of isolated anti-P antibodies may discriminate patients with pure class V lupus nephritis, whereas the simultaneous presence of anti-dsDNA antibodies suggests class V disease with concomitant proliferative lesions. These observations lead to the hypothesis that anti-P and anti-dsDNA might result in membraneous changes and proliferative changes, respectively, although further investigation is required for confirmation.

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“…In this regard, anti‐ribosomal P proteins antibodies (anti‐rib P), which are highly specific markers for systemic lupus erythematosus (SLE) , have been reported to occur in a higher prevalence in lupus patients with liver involvement than in patients without this complication . The potential pathogenic role of anti‐rib P antibodies in liver disease was supported by the ability of these antibodies to penetrate into live hepatocytes, causing cellular dysfunction .…”

mentioning

confidence: 99%