Single-atom nanozymes: classification, regulation strategy, and safety concerns

Han, Jiping; Gu, Yaohua; Yang, Changyi; Meng, Lingchen; Ding, Runmei; Wang, Yifan; Shi, Keren; Yao, Huiqin

doi:10.1039/d3tb01644g

Cited by 8 publications

(3 citation statements)

References 172 publications

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“…A leader in the field of catalysis, enzymes with atomically dispersed active sites are distinguished by their outstanding performance. Researchers highly value the following characteristics of SAzymes: optimal atom utilization rate, economical cost, clearly defined coordination structure, and active sites [ 66 ]. SAzyme is the current focal point of NZ research.…”

Section: Classifications Of Antibacterial Nanozymesmentioning

confidence: 99%

The potential use of nanozymes as an antibacterial agents in oral infection, periodontitis, and peri-implantitis

Hosseini Hooshiar,

Badkoobeh,

Kolahdouz

et al. 2024

J Nanobiotechnol

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Several studies suggest that oral pathogenic biofilms cause persistent oral infections. Among these is periodontitis, a prevalent condition brought on by plaque biofilm. It can even result in tooth loss. Furthermore, the accumulation of germs around a dental implant may lead to peri-implantitis, which damages the surrounding bone and gum tissue. Furthermore, bacterial biofilm contamination on the implant causes soft tissue irritation and adjacent bone resorption, severely compromising dental health. On decontaminated implant surfaces, however, re-osseointegration cannot be induced by standard biofilm removal techniques such as mechanical cleaning and antiseptic treatment. A family of nanoparticles known as nanozymes (NZs) comprise highly catalytically active multivalent metal components. The most often employed NZs with antibacterial activity are those that have peroxidase (POD) activity, among other types of NZs. Since NZs are less expensive, more easily produced, and more stable than natural enzymes, they hold great promise for use in various applications, including treating microbial infections. NZs have significantly contributed to studying implant success rates and periodontal health maintenance in periodontics and implantology. An extensive analysis of the research on various NZs and their applications in managing oral health conditions, including dental caries, dental pulp disorders, oral ulcers, peri-implantitis, and bacterial infections of the mouth. To combat bacteria, this review concentrates on NZs that imitate the activity of enzymes in implantology and periodontology. With a view to the future, there are several ways that NZs might be used to treat dental disorders antibacterially. Graphical Abstract

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Section: Classifications Of Antibacterial Nanozymesmentioning

confidence: 99%

The potential use of nanozymes as an antibacterial agents in oral infection, periodontitis, and peri-implantitis

Hosseini Hooshiar,

Badkoobeh,

Kolahdouz

et al. 2024

J Nanobiotechnol

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“…The emergence of single-atom nanozymes not only breaks through the limitations of biological enzymes but also improves the catalytic performance to a great extent by using atomic-level sites as the active center. 18,19 Meanwhile, features such as maximized atom utilization and clear electronic coordination structure are favorable for combining with electrochemical detection technology.…”

Section: Introductionmentioning

confidence: 99%

“…Due to the features including low economic cost, miniaturization, and adaptability to multiple scenarios. , Simultaneously, electrochemical detection technology can be well combined with flexible wearable devices to achieve real-time detection of the physiological state of certain substances for the purpose of personalized medical testing. , The electrode modification material is critical to determine the accuracy of electrochemical detection. The emergence of single-atom nanozymes not only breaks through the limitations of biological enzymes but also improves the catalytic performance to a great extent by using atomic-level sites as the active center. , Meanwhile, features such as maximized atom utilization and clear electronic coordination structure are favorable for combining with electrochemical detection technology.…”

Section: Introductionmentioning

confidence: 99%

Co Single-Atom Nanozymes for the Simultaneous Electrochemical Detection of Uric Acid and Dopamine in Biofluids

Liu,

Zhang,

Wang

et al. 2024

ACS Appl. Nano Mater.

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The development of enzyme-like electrochemical sensors with atomic-level catalytic activity sites is essential for the accurate and sensitive detection of active molecules in biological fluids. In this study, a sensitive signal amplification platform for simultaneous analysis of dopamine (DA) and uric acid (UA) was prepared on a screen-printed carbon electrode (SPCE). The sensing platform combines polypyrrole (Ppy) with high electrical conductivity and cobalt single-atom nanozymes of tubular bisparaben nitrogen-carbon (Co-NNC) with excellent strong oxidase activity, named Ppy-Co-NNC/SPCE. The single-atom catalytic process and detection mechanism were investigated by using density functional theory. DA and UA were simultaneously detected in the ranges of 1−50 and 2−500 μM with detection limits as low as 0.025 and 0.411 μM, respectively. In addition, real-time detection of uric acid in sweat under resting and exercising conditions was achieved using a poly(vinyl alcohol) hydrogel as a sweat collector in combination with Ppy-Co-NNC/SPCE. Moreover, the simultaneous detection of UA and DA in human urine was also achieved. The method provides a new strategy for the detection of small molecules in biofluids, which is promising for sensing and personalized medicine.

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Concave single-atom Co nanozymes with densely edge-hosted active sites for highly sensitive immunoassay

Xu,

Tao,

Jiang

et al. 2024

Chemical Engineering Journal

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Single-atom nanozymes: classification, regulation strategy, and safety concerns

Abstract: Nanozymes, nanomaterials possessing enzymatic activity, have been studied extensively by researchers. However, their complex composition, low density of active sites, and inadequate substrate selectivity have hindered the maturation and widespread...

Cited by 8 publications

References 172 publications

The potential use of nanozymes as an antibacterial agents in oral infection, periodontitis, and peri-implantitis

The potential use of nanozymes as an antibacterial agents in oral infection, periodontitis, and peri-implantitis

Co Single-Atom Nanozymes for the Simultaneous Electrochemical Detection of Uric Acid and Dopamine in Biofluids

Concave single-atom Co nanozymes with densely edge-hosted active sites for highly sensitive immunoassay

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