“…Prevention of anxiety, both from the patient and caregivers' perspective, was the most common primary outcome of interest, accounting for over a fifth of studies (n=20, 23%). 32,37,38,49,53,54,57,58,59,63,70,71,79,81,91,93,94,103,105,108 Prevention of anxiety was a secondary outcome of interest in a further nine (10%) studies. 22,23,25,47,50,55,69,73,80 Of the studies including anxiety prevention as the primary outcome, nine studies (47%) were focused on adult patients; 32,38,53,57,59,71,81,94,105 nine were focused on pediatric patients, 37,49,54,63,79,91,93,103,108 (with four of these also including caregivers as a sub-population, …”