Single bolus intravenous regadenoson injection versus central venous infusion of adenosine for maximum coronary hyperaemia in fractional flow reserve measurement

Abstract

Maximum coronary hyperaemia can be achieved easily, rapidly, and safely by one single intravenous bolus of regadenoson administered either centrally or peripherally. Repeated regadenoson injections are safe. The hyperaemic plateau is variable. Clinical Trial Registration: http://clinicaltrials.gov/ct2/ show/study/NCT01809743?term=NCT01809743&rank=1 (ClinicalTrials.gov Identifier: NCT01809743).

Variability of fractional flow reserve according to the methods of hyperemia induction

“…The study analyzed pooled data from 4 previously published studies . All the included studies required that each study protocol be approved by the institutional review board of each center and that participants provide written informed consent.…”

REVascularization with paclitaxEL‐coated balloon angioplasty versus drug‐eluting stenting in acute myocardial infarcTION—A randomized controlled trial: Rationale and design of the REVELATION trial

“…FFR will be performed with the “Prime Wire Prestige Plus Straight” (Volcano Corporation, San Diego, CA). Maximum hyperaemia will be induced by intravenous administration of regadenoson (400 μg bolus) with expected steady state after 30 seconds . The pressure sensor will be positioned at least 5 mm distal to the treated segment and recording will be obtained.…”

Variability of Fractional Flow Reserve According to the Various Methods to Induce Hyperemia

“…The study analyzed pooled data from 4 previously published studies [5,10,13,14]. All the included studies required that each study protocol be approved by the institutional review board of each center and that participants provide written informed consent.…”