Single Bone Metastasis from Adenocarcinoma of the Lacrimal Gland: A Case Report

Abstract

Malignant tumors of the lacrimal gland are rare, and single bone metastases from lacrimal gland carcinoma are an exceptional event. We present the case of a 71-year-old man with a history of lumbar pain and left exophthalmos. Surgical resection of the lacrimal lesion and a bone biopsy gave a final histopathological diagnosis of primary ductal adenocarcinoma of the lacrimal gland with bone metastasis. The pathological tissue from both procedures was positive for androgen receptor expression. The patient underwent embolization and radiotherapy in association with total androgen blockade. After 20 months, the patient is still asymptomatic and has maintained the partial response at L1 with no progression to other sites. Our patient would appear to have a better prognosis and the disease a more indolent clinical course than the other cases of ductal adenocarcinoma of the lacrimal gland reported in the literature.

Lacrimal gland ductal carcinomas: Clinical, Morphological and Genetic characterization and implications for targeted treatment

“…Lending further support to the role of androgen‐deprivation therapy in managing DC is the favourable response in one patient with skeletal metastases from an AR+ DC (Ricci et al. ).…”

“…Androgen-deprivation therapy is currently emerging in the management of AR+ breast carcinomas, and has shown clinical response in SDC with a clinical trial currently enrolling patients (clinicaltrials.gov identifier: NCT01969578) (Jaspers et al 2011;Gucalp et al 2013;Nardi et al 2013;Hickey et al 2015). Lending further support to the role of androgen-deprivation therapy in managing DC is the favourable response in one patient with skeletal metastases from an AR+ DC (Ricci et al 2014).…”

“…; Ricci et al. ). Despite anti‐HER2 and androgen‐deprivation therapy being interesting treatment strategies in the management of DC, the frequency of which HER2 protein and steroid hormone receptors is expressed in DC remains unknown.…”

“…Although ER-directed antihormonal therapy is currently used in ER+ breast carcinoma, androgen-deprivation therapy of ERÀ/AR+ breast carcinomas is gaining increased attention (Hickey et al 2015). Androgen-deprivation therapy has shown some effect in SDC and also in one case of metastatic DC (Jaspers et al 2011;Ricci et al 2014). Despite anti-HER2 and androgen-deprivation therapy being interesting treatment strategies in the management of DC, the frequency of which HER2 protein and steroid hormone receptors is expressed in DC remains unknown.…”

Metastatic Osteosarcoma of Lacrimal Gland

“…1,2 Single bone metastasis from adenocarcinoma of lacrimal gland has been reported. 3 Also metastasis of osteosarcoma to the orbit is known. 4 In this manuscript we report metastasis of osteosarcoma of long bone to the lacrimal gland.…”