Single-cell aggrephagy-related patterns facilitate tumor microenvironment intercellular communication, influencing osteosarcoma progression and prognosis

Jiang, Yunsheng; Ning, Yun; Cheng, Shidi; Huang, Yinde; Deng, Muhai; Chen, Cheng

doi:10.1007/s10495-023-01922-5

Cited by 1 publication

(2 citation statements)

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“…Tumor microenvironment modulators in osteosarcoma immunotherapy have shown immense potential. Jiang et al conducted a comprehensive analysis of single-cell samples from osteosarcoma, revealing the role of genes associated with aggregated autophagy, suggesting that interventions targeting aggregated autophagy may improve survival rates and quality of life for patients with osteosarcoma ( Jiang et al, 2023 ). Huang et al identified the significant immunomodulatory effects of Methionine Enkephalin (MENK) in osteosarcoma treatment.…”

Section: Osteosarcoma Treatmentmentioning

confidence: 99%

“…Yu et al's approach in treating pulmonary metastatic osteosarcoma involves engineered hepatic genetic circuits for efficient VEGFR2 siRNA delivery, directly targeting tumor cells, diminishing adverse drug reactions, and potentially improving immune cell functionality (Yu et al, 2023). Furthermore, research by Cheng et al revealed that Psoralidin inhibits osteosarcoma growth and metastasis by targeting the FAK and PI3K/Akt signaling pathways and downregulating ITGB1 expression (Cheng S. et al, 2023). Regarding molecular mechanisms, Wu et al indicated that FGD1 promotes tumor progression by inhibiting PTEN activity, with overexpression associated with poor prognosis in osteosarcoma patients, activating the PI3K/AKT signaling pathway, and affecting tumor cell behavior, suggesting FGD1 as a potential target for improving osteosarcoma treatment outcomes (Wu et al, 2020).…”

Section: Targeted Therapiesmentioning

confidence: 99%

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Advancements in osteosarcoma management: integrating immune microenvironment insights with immunotherapeutic strategies

Liang,

Cui,

et al. 2024

Front. Cell Dev. Biol.

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Osteosarcoma, a malignant bone tumor predominantly affecting children and adolescents, presents significant therapeutic challenges, particularly in metastatic or recurrent cases. Conventional surgical and chemotherapeutic approaches have achieved partial therapeutic efficacy; however, the prognosis for long-term survival remains bleak. Recent studies have highlighted the imperative for a comprehensive exploration of the osteosarcoma immune microenvironment, focusing on the integration of diverse immunotherapeutic strategies—including immune checkpoint inhibitors, tumor microenvironment modulators, cytokine therapies, tumor antigen-specific interventions, cancer vaccines, cellular therapies, and antibody-based treatments—that are directly pertinent to modulating this intricate microenvironment. By targeting tumor cells, modulating the tumor microenvironment, and activating host immune responses, these innovative approaches have demonstrated substantial potential in enhancing the effectiveness of osteosarcoma treatments. Although most of these novel strategies are still in research or clinical trial phases, they have already demonstrated significant potential for individuals with osteosarcoma, suggesting the possibility of developing new, more personalized and effective treatment options. This review aims to provide a comprehensive overview of the current advancements in osteosarcoma immunotherapy, emphasizing the significance of integrating various immunotherapeutic methods to optimize therapeutic outcomes. Additionally, it underscores the imperative for subsequent research to further investigate the intricate interactions between the tumor microenvironment and the immune system, aiming to devise more effective treatment strategies. The present review comprehensively addresses the landscape of osteosarcoma immunotherapy, delineating crucial scientific concerns and clinical challenges, thereby outlining potential research directions.

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Section: Osteosarcoma Treatmentmentioning

confidence: 99%