Single-cell analysis of the amphioxus hepatic caecum and vertebrate liver reveals genetic mechanisms of vertebrate liver evolution

Wu, Baosheng; Xu, Wenjie; Wu, Kunjin; Li, Ye; Hu, Mingliang; Feng, Chenguang; Zhu, Chenglong; Zheng, Jiangmin; Cui, Xinxin; Li, Jing; Fan, Deqian; Zhang, Fenghua; Liu, Yuxuan; Chen, Jinping; Liu, Chang; Li, Guang; Qiu, Qiang; Qu, Kai; Wang, Wen; Wang, Kun

doi:10.1038/s41559-024-02510-9

Nat Ecol Evol

2024

DOI: 10.1038/s41559-024-02510-9

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Single-cell analysis of the amphioxus hepatic caecum and vertebrate liver reveals genetic mechanisms of vertebrate liver evolution

Baosheng Wu,

Wenjie Xu,

Kunjin Wu

et al.

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Cited by 2 publications

References 93 publications

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Gene duplication contributes to liver evolution

Hervas-Sotomayor,

Murat

2024

Nat Ecol Evol

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Gene duplication contributes to liver evolution

Hervas-Sotomayor,

Murat

2024

Nat Ecol Evol

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Metabolic complementation between cells drives the evolution of tissues and organs

Pavlicev,

DiFrisco,

Love

et al. 2024

Biol. Lett.

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Although evolutionary transitions of individuality have been extensively theorized, little attention has been paid to the origin of levels of organization within organisms. How and why do specialized cells become organized into specialized tissues or organs? What spurs a transition in organizational level in cases where the function is already present in constituent cell types? We propose a hypothesis for this kind of evolutionary transition based on two features of cellular metabolism: metabolic constraints on functional performance and the capacity for metabolic complementation between parenchymal and supporting cells. These features suggest a scenario whereby pre-existing specialized cell types are integrated into tissues when changes to the internal or external environment favour offloading metabolic burdens from a primary specialized cell type onto supporting cells. We illustrate this process of ‘supra-functionalization’ using the nervous system and pancreas.

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Single-cell analysis of the amphioxus hepatic caecum and vertebrate liver reveals genetic mechanisms of vertebrate liver evolution

Cited by 2 publications

References 93 publications

Gene duplication contributes to liver evolution

Gene duplication contributes to liver evolution

Metabolic complementation between cells drives the evolution of tissues and organs

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