Single-cell analysis of the miRNA activities in tuberculous meningitis (TBM) model mice injected with the BCG vaccine

Zhang, Xiaolin; Pan, Lei; Zhang, Peng; Wang, Lei; Shen, Yidan; Xu, Ping; Ren, Yang; Huang, Wei; Liu, Ping; Wu, Qingguo; Li, Feng

doi:10.1016/j.intimp.2023.110871

International Immunopharmacology

2023

DOI: 10.1016/j.intimp.2023.110871

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Single-cell analysis of the miRNA activities in tuberculous meningitis (TBM) model mice injected with the BCG vaccine

Xiaolin Zhang,

Lei Pan,

Peng Zhang

et al.

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2024

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Cited by 3 publications

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Non-coding RNAs in meningitis: Key regulators of immune response and inflammation

Imran,

Abida,

Kamal

et al. 2024

Pathology - Research and Practice

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Non-coding RNAs in meningitis: Key regulators of immune response and inflammation

Imran,

Abida,

Kamal

et al. 2024

Pathology - Research and Practice

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Single‐cell sequencing: Current applications in various tuberculosis specimen types

Zeng,

Ma,

Chen

et al. 2024

Cell Proliferation

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Tuberculosis (TB) is a chronic disease caused by Mycobacterium tuberculosis (M.tb) and responsible for millions of deaths worldwide each year. It has a complex pathogenesis that primarily affects the lungs but can also impact systemic organs. In recent years, single‐cell sequencing technology has been utilized to characterize the composition and proportion of immune cell subpopulations associated with the pathogenesis of TB disease since it has a high resolution that surpasses conventional techniques. This paper reviews the current use of single‐cell sequencing technologies in TB research and their application in analysing specimens from various sources of TB, primarily peripheral blood and lung specimens. The focus is on how these technologies can reveal dynamic changes in immune cell subpopulations, genes and proteins during disease progression after M.tb infection. Based on the current findings, single‐cell sequencing has significant potential clinical value in the field of TB research. Next, we will focus on the real‐world applications of the potential targets identified through single‐cell sequencing for diagnostics, therapeutics and the development of effective vaccines.

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Ependymal cells: roles in central nervous system infections and therapeutic application

Xie,

2024

J Neuroinflammation

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Ependymal cells are arranged along the inner surfaces of the ventricles and the central canal of the spinal cord, providing anatomical, physiological and immunological barriers that maintain cerebrospinal fluid (CSF) homeostasis. Based on this, studies have found that alterations in gene expression, cell junctions, cytokine secretion and metabolic disturbances can lead to dysfunction of ependymal cells, thereby participating in the onset and progression of central nervous system (CNS) infections. Additionally, ependymal cells can exhibit proliferative and regenerative potential as well as secretory functions during CNS injury, contributing to neuroprotection and post-injury recovery. Currently, studies on ependymal cell primarily focus on the basic investigations of their morphology, function and gene expression; however, there is a notable lack of clinical translational studies examining the molecular mechanisms by which ependymal cells are involved in disease onset and progression. This limits our understanding of ependymal cells in CNS infections and the development of therapeutic applications. Therefore, this review will discuss the molecular mechanism underlying the involvement of ependymal cells in CNS infections, and explore their potential for application in clinical treatment modalities.

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Single-cell analysis of the miRNA activities in tuberculous meningitis (TBM) model mice injected with the BCG vaccine

Cited by 3 publications

References 46 publications

Non-coding RNAs in meningitis: Key regulators of immune response and inflammation

Non-coding RNAs in meningitis: Key regulators of immune response and inflammation

Single‐cell sequencing: Current applications in various tuberculosis specimen types

Ependymal cells: roles in central nervous system infections and therapeutic application

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