2018
DOI: 10.1101/394304
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Single-cell analysis reveals the KIT D816V mutation in hematopoietic stem and progenitor cells in systemic mastocytosis: Supplementary data

Abstract: 32Background: Systemic mastocytosis (SM) is a hematological disease characterized 33 by organ infiltration by neoplastic mast cells. Almost all SM patients have a mutation 34 in the gene encoding the tyrosine kinase receptor KIT causing a D816V substitution 35 and autoactivation of the receptor. Mast cells and CD34 + hematopoietic progenitors 36 can carry the mutation, however, in which progenitor cell subset the mutation arises is 37 unknown. We aimed to investigate the distribution of the D816V mutation in s… Show more

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