Single-cell and bulk RNA sequencing highlights the role of M1-like infiltrating macrophages in antibody-mediated rejection after kidney transplantation

Pang, Qidan; Chen, Liang; An, Changyong; Zhou, Juan; Xiao, Hanyu

doi:10.1016/j.heliyon.2024.e27865

Heliyon

2024

DOI: 10.1016/j.heliyon.2024.e27865

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Single-cell and bulk RNA sequencing highlights the role of M1-like infiltrating macrophages in antibody-mediated rejection after kidney transplantation

Qidan Pang,

Liang Chen,

Changyong An

et al.

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Single-Cell RNA Sequencing in Organ and Cell Transplantation

Abedini-Nassab,

Taheri,

Emamgholizadeh

et al. 2024

Biosensors

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Single-cell RNA sequencing is a high-throughput novel method that provides transcriptional profiling of individual cells within biological samples. This method typically uses microfluidics systems to uncover the complex intercellular communication networks and biological pathways buried within highly heterogeneous cell populations in tissues. One important application of this technology sits in the fields of organ and stem cell transplantation, where complications such as graft rejection and other post-transplantation life-threatening issues may occur. In this review, we first focus on research in which single-cell RNA sequencing is used to study the transcriptional profile of transplanted tissues. This technology enables the analysis of the donor and recipient cells and identifies cell types and states associated with transplant complications and pathologies. We also review the use of single-cell RNA sequencing in stem cell implantation. This method enables studying the heterogeneity of normal and pathological stem cells and the heterogeneity in cell populations. With their remarkably rapid pace, the single-cell RNA sequencing methodologies will potentially result in breakthroughs in clinical transplantation in the coming years.

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Single-Cell RNA Sequencing in Organ and Cell Transplantation

Abedini-Nassab,

Taheri,

Emamgholizadeh

et al. 2024

Biosensors

View full text Add to dashboard Cite

show abstract

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Single-cell and bulk RNA sequencing highlights the role of M1-like infiltrating macrophages in antibody-mediated rejection after kidney transplantation

Cited by 1 publication

References 80 publications

Single-Cell RNA Sequencing in Organ and Cell Transplantation

Single-Cell RNA Sequencing in Organ and Cell Transplantation

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