Dynamic DNA nanostructures are DNA nanostructures with
reconfigurable
elements that can undergo structural transformations in response to
specific stimuli. Thus, anchoring dynamic DNA nanostructures on cell
membranes is an attractive and promising strategy for well-controlled
cell manipulation. Here, we review the latest progress in dynamic
DNA nanostructures for cell manipulation. Commonly used mechanisms
for dynamic DNA nanostructures are first introduced. Subsequently,
we summarize the anchoring strategies for dynamic DNA nanostructures
on cell membranes and list possible applications (including programming
cell membrane receptors, controlling ligand activity and drug delivery,
capturing and releasing cells, and assembling cells into clusters).
Finally, insights into the remaining challenges are presented.