2024
DOI: 10.1038/s41592-024-02360-0
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Single-cell EpiChem jointly measures drug–chromatin binding and multimodal epigenome

Chao Dong,
Xiaoxuan Meng,
Tong Zhang
et al.

Abstract: Studies of molecular and cellular functions of small-molecule inhibitors in cancer treatment, eliciting effects by targeting genome and epigenome associated proteins, requires measurement of drug-target engagement in single-cell resolution. Here we present EpiChem for in situ single-cell joint mapping of small molecules and multimodal epigenomic landscape. We demonstrate single-cell co-assays of three small molecules together with histone modifications, chromatin accessibility or target proteins in human color… Show more

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