2021
DOI: 10.3390/min11020191
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Single-Cell Imaging for Studies of Renal Uranium Transport and Intracellular Behavior

Abstract: Nephrotoxicity is the primary health effect of uranium exposure. However, the renal transport and intracellular behavior of uranium remains to be clearly elucidated. In the present study, the intracellular uranium distribution was examined with the cell lines derived from the S3 segment of mouse renal proximal tubules, which is a toxic target site of uranium, using microbeam-based elemental analysis. Uranium exposure at 100 μM for 24 h (non-toxic phase) was performed in S3 cells. Two types of measurement speci… Show more

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Cited by 5 publications
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“…The chemical mapping using µ-PIXE, SR-µ-XRF, and µ-XAFS with sub-micrometer resolution revealed that uranium was concentrated in the phosphorusconcentrated area as U(VI) state in the proximal tubules of the kidney of uranyl acetate-treated rats [8]. Single-cell analysis using µ-PIXE revealed the intracellular distribution of uranium in perinuclear regions [9].…”
mentioning
confidence: 99%
“…The chemical mapping using µ-PIXE, SR-µ-XRF, and µ-XAFS with sub-micrometer resolution revealed that uranium was concentrated in the phosphorusconcentrated area as U(VI) state in the proximal tubules of the kidney of uranyl acetate-treated rats [8]. Single-cell analysis using µ-PIXE revealed the intracellular distribution of uranium in perinuclear regions [9].…”
mentioning
confidence: 99%