2019
DOI: 10.7554/elife.52004
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Single cell transcriptional signatures of the human placenta in term and preterm parturition

Abstract: More than 135 million births occur each year; yet, the molecular underpinnings of human parturition in gestational tissues, and in particular the placenta, are still poorly understood. The placenta is a complex heterogeneous organ including cells of both maternal and fetal origin, and insults that disrupt the maternal-fetal dialogue could result in adverse pregnancy outcomes such as preterm birth. There is limited knowledge of the cell type composition and transcriptional activity of the placenta and its compa… Show more

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Cited by 233 publications
(314 citation statements)
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“…Cell entry and spreading of SARS-CoV-2 has been widely thought to depend on the angiotensinconverting enzyme 2 (ACE2) receptor [57,58] and the serine protease TMPRSS2 [59]. In the study herein, we investigated whether the receptors responsible for SARS-CoV-2 infection are expressed in the human placenta (including the decidual tissues) throughout the three trimesters of pregnancy using publicly available single-cell RNA-sequencing (scRNA-seq) data [60,61] together with newly generated data (Table S1).…”
Section: Main Textmentioning
confidence: 99%
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“…Cell entry and spreading of SARS-CoV-2 has been widely thought to depend on the angiotensinconverting enzyme 2 (ACE2) receptor [57,58] and the serine protease TMPRSS2 [59]. In the study herein, we investigated whether the receptors responsible for SARS-CoV-2 infection are expressed in the human placenta (including the decidual tissues) throughout the three trimesters of pregnancy using publicly available single-cell RNA-sequencing (scRNA-seq) data [60,61] together with newly generated data (Table S1).…”
Section: Main Textmentioning
confidence: 99%
“…multinucleated cells) cell types. This is likely the reason why the reported scRNA-seq studies of the human placenta contain a low fraction of syncytiotrophoblast cells [STB, multinucleated cells forming the outermost fetal component of the placenta in direct contact with the maternal circulation (i.e., intervillous space)] [60,61,65]. Therefore, we considered whether the expression of ACE2 and TMPRSS2 was minimally observed in the placental cell types due to the reduced fraction of STB cells (i.e., dissociation bias).…”
Section: Main Textmentioning
confidence: 99%
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