Single-cell transcriptomic landscape identifies the expansion of peripheral blood monocytes as an indicator of HIV-1-TB co-infection

Guo, Qing; Zhong, Yu; Wang, Zhifeng; Cao, Tingzhi; Zhang, Mingyuan; Zhang, Peiyan; Huang, Waidong; Bi, Jing; Yuan, Yue; Ou, Min; Zou, Xudong; Xiao, Guohui; Yuan, Yang; Liu, Shiping; Liu, Longqi; Wang, Zhaoqin; Zhang, Guoliang; Wu, Liang

doi:10.1016/j.cellin.2022.100005

Cited by 11 publications

(7 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Monocytes, which are important in recruiting immune cells to the lungs are also increased in HIV/TB patients ( 253 , 254 ). Increased accumulation of inflammatory CD14 + CD16 + monocytes are seen in HIV/TB coinfected patients ( 255 ). HIV patients with prior exposure to TB had increased monocyte activation, contributing to TB pathogenesis ( 256 ).…”

Section: Major Immune Cells In Innate Host Defense Against Tbmentioning

confidence: 99%

Early innate cell interactions with Mycobacterium tuberculosis in protection and pathology of tuberculosis

Sankar,

Mishra

2023

Front. Immunol.

View full text Add to dashboard Cite

Tuberculosis (TB) remains a significant global health challenge, claiming the lives of up to 1.5 million individuals annually. TB is caused by the human pathogen Mycobacterium tuberculosis (Mtb), which primarily infects innate immune cells in the lungs. These immune cells play a critical role in the host defense against Mtb infection, influencing the inflammatory environment in the lungs, and facilitating the development of adaptive immunity. However, Mtb exploits and manipulates innate immune cells, using them as favorable niche for replication. Unfortunately, our understanding of the early interactions between Mtb and innate effector cells remains limited. This review underscores the interactions between Mtb and various innate immune cells, such as macrophages, dendritic cells, granulocytes, NK cells, innate lymphocytes-iNKT and ILCs. In addition, the contribution of alveolar epithelial cell and endothelial cells that constitutes the mucosal barrier in TB immunity will be discussed. Gaining insights into the early cellular basis of immune reactions to Mtb infection is crucial for our understanding of Mtb resistance and disease tolerance mechanisms. We argue that a better understanding of the early host-pathogen interactions could inform on future vaccination approaches and devise intervention strategies.

show abstract

Section: Major Immune Cells In Innate Host Defense Against Tbmentioning

confidence: 99%

Early innate cell interactions with Mycobacterium tuberculosis in protection and pathology of tuberculosis

Sankar,

Mishra

2023

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…The immune system may play a pivotal function in the potentiating effects between HIV and TB infections ( 82 ), and possibly their effects on the brain. For example, the proportion of peripheral blood CD14 + CD16 + monocytes are higher in TB and HIV coinfected patients as compared to people living with HIV but without TB infection ( 83 ). CD14 + CD16 + monocytes that are infected with HIV, migrate across the BBB, which is the primary mechanism by which HIV infects the CNS ( 84 ), resulting in cognitive impairment.…”

Section: (Neuro)inflammatory Markers In Pediatric Hivmentioning

confidence: 99%

Biomarkers of Tuberculous Meningitis and Pediatric Human Immunodeficiency Virus on the African Continent

2022

View full text Add to dashboard Cite

Biomarkers in body fluids are helpful objective tools in diagnosis, prognosis and monitoring of (therapeutic) responses of many neurological diseases. Cerebrospinal fluid (CSF) biomarkers are part of the diagnostic toolbox for infectious neurological diseases. Tuberculous meningitis (TBM) and Human immunodeficiency virus (HIV), are important burdens of disease in Africa and can negatively affect brain health. Two thirds of the world's population of people living with HIV reside in sub-Saharan Africa and 25% of the global burden of tuberculosis (TB) is carried by the African continent. Neuroinflammation and damage of specific neuronal cell types are key constituents in the pathophysiology of these central nervous system (CNS) diseases, and important potential sources of circulating biomarkers. In this review, we summarize current research in the use of biomarkers in TBM and pediatric HIV as case demonstrations for high prevalence neurological diseases in Africa. Inflammatory molecules, primarily when detected in CSF, appear to have diagnostic value in these diseases, especially when measured as profiles. Brain injury molecules, such as S100, Neuron specific enolase and glial fibrillary acidic protein may have prognostic value in TBM, but more studies are needed. There is a need for more cost-economic and high sensitivity technologies to drive further biomarker discoveries and translate into healthcare improvements for these important healthcare problems in a globally fair way.

show abstract

“…Moreover, Mtb infection is the leading cause of mortality in individuals with HIV-1. TB and HIV-1 coinfection can disrupt the host immune system, especially by impairing CD4 + T cells and macrophages ( Guo et al., 2022 ). The development of innovative diagnostic methods, drugs, and vaccines is crucial in addressing these challenges effectively.…”

Section: Introductionmentioning

confidence: 99%

Optimizing antigen selection for the development of tuberculosis vaccines

Yang,

Chen,

Xia

2024

Cell Insight

View full text Add to dashboard Cite

Single-cell transcriptomic landscape identifies the expansion of peripheral blood monocytes as an indicator of HIV-1-TB co-infection

Cited by 11 publications

References 88 publications

Early innate cell interactions with Mycobacterium tuberculosis in protection and pathology of tuberculosis

Early innate cell interactions with Mycobacterium tuberculosis in protection and pathology of tuberculosis

Biomarkers of Tuberculous Meningitis and Pediatric Human Immunodeficiency Virus on the African Continent

Optimizing antigen selection for the development of tuberculosis vaccines

Contact Info

Product

Resources

About