Single-center experience in the diagnosis and treatment of lymphoepithelioma-like hepatic carcinoma

Jia, Junjun; Guo, Hongkai; Liu, Jiabin; Sun, Qi; Cao, Gengyu; Shao, Zengwu; Shuai, Mingqi; Gao, Feng; Zheng, Shusen; Zhang, Min

doi:10.1007/s00432-023-04808-w

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…An undifferentiated nasopharyngeal carcinoma, which was characterized by epithelial neoplastic cells developing in solid or incohesive sheets mixed with a noticeable lymphoid infiltration, was first named lymphoepithelioma by Carbone in 1982 [9]. LELC had similar histological features with lymphoepithelioma but primarily occurred in other organs, such as the esophagus [3], thymus [4], lungs [5], stomach [6], and liver [7]. LELC in the urinary system is rare, most common in the bladder, followed by the renal pelvis [10], ureter [11], and urethra [12].…”

Section: Discussionmentioning

confidence: 99%

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A Case of Primary Lymphoepithelioma-Like Carcinoma of the Bladder With Review

Zheng¹,

Yu²,

Du³

et al. 2023

Cureus

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Lymphoepithelioma-like carcinoma (LELC) was characterized by epithelial neoplastic cells developing in solid or incohesive sheets mixed with a noticeable lymphoid infiltration. Lymphoepithelioma-like carcinoma of the bladder (LELCB), which was first described by Zukerberg, is a rare variant of LELC. Here we reported a new case of LELCB occurring in a 70-year-old woman presenting with hematuria. Computed tomography (CT) and cystoscopy revealed a tumor on the left upper wall of the bladder. A partial cystectomy was finally performed. Pathological and immunohistochemical analysis revealed LELCB. After receiving systemic adjuvant chemotherapy, the patient conducted a 25-month follow-up without experiencing a recurrence.

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Section: Discussionmentioning

confidence: 99%

“…Lymphoepithelioma-like carcinoma (LELC) or lymphoepithelioma carcinoma is a rare malignant epithelial tumor characterized by lymphocytic interstitial hyperplasia [1]. It is most common in the nasopharynx [2], followed by the esophagus [3], thymus [4], lungs [5], stomach [6], and liver [7]. Primary LELC of the urinary system is rare.…”

Section: Introductionmentioning

confidence: 99%

A Case of Primary Lymphoepithelioma-Like Carcinoma of the Bladder With Review

Zheng¹,

Yu²,

Du³

et al. 2023

Cureus

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Clinicopathologic features and tumor immune microenvironment of lymphocyte-rich hepatocellular carcinoma

Zhang,

Zhao,

et al. 2024

Annals of Diagnostic Pathology

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Lymphoepithelial Carcinoma of the Lung: A Case Report and Review of the Literature

Samaras,

Koufopoulos,

Mitsos

et al. 2024

Cureus

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Lymphoepithelial or lymphoepithelioma-like carcinoma is a poorly differentiated carcinoma located outside the nasopharynx with similar morphologic characteristics to its nasopharyngeal counterpart. Lymphoepithelial carcinoma of the lung is a rare subtype of squamous cell lung carcinoma frequently associated with Epstein-Barr virus (EBV) infection, accounting for approximately 1% of non-small cell lung carcinomas (NSCLC). We herewith present a case of a 78-year-old female patient who was diagnosed with lymphoepithelial carcinoma of the lung, emphasizing its distinct epidemiological features, clinical workup, and histopathological characteristics. Furthermore, we discuss its histologic differential diagnosis. Finally, we refer to this tumor's unique molecular and immunological profile and its treatment modalities, and we review the literature.

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Single-center experience in the diagnosis and treatment of lymphoepithelioma-like hepatic carcinoma

Cited by 3 publications

References 12 publications

A Case of Primary Lymphoepithelioma-Like Carcinoma of the Bladder With Review

A Case of Primary Lymphoepithelioma-Like Carcinoma of the Bladder With Review

Clinicopathologic features and tumor immune microenvironment of lymphocyte-rich hepatocellular carcinoma

Lymphoepithelial Carcinoma of the Lung: A Case Report and Review of the Literature

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