Single Center Review of Clinicopathological Characterization in 77 Patients with Positive Lupus Anticoagulant Antibodies

Abstract

We find that thrombosis, venous or arterial, and obstetric complications are the most frequent clinical findings in our patients with circulating LAC. Incidental APS is not an uncommon finding in patients screened for APS. There is a clear association between the presence of LAC and an abnormal aPTT, which is much less obvious with the PT.

Does rotational thromboelastometry accurately predict coagulation status in patients with lupus anticoagulant?

“…Fourteen children (12 girls, 2 boys) averaging 16 (12)(13)(14)(15)(16)(17)(18) years old at time of collection with prior diagnosis of SLE or APS were included in this study. Glucocorticoids had been given in 93% (13/14) of the patients, and all were taking hydroxychloroquine.…”

“…The prevalence of LA is reported to be approximately 3.5% in healthy adult blood donors and 34% in patients with systemic lupus erythematosus (SLE) . Clinical manifestations of lupus anticoagulant include venous and arterial thrombosis, pulmonary embolism, recurrent pregnancy loss, livedo reticularis, and stroke . The diagnosis of antiphospholipid syndrome (APS) requires both thrombotic events and/or pregnancy loss with laboratory confirmation based on the modified Sapporo criteria .…”

“…15,16 Clinical manifestations of lupus anticoagulant include venous and arterial thrombosis, pulmonary embolism, recurrent pregnancy loss, livedo reticularis, and stroke. 17 The diagnosis of antiphospholipid syndrome (APS) requires both thrombotic events and/or pregnancy loss with laboratory confirmation based on the modified Sapporo criteria. 18 LA is widely recognized as causing abnormal values in several coagulation assays, most notably prolongation of the APTT, due to binding of antibody to proteins with high affinity for phospholipids.…”

Evaluating hypercoagulability in new‐onset systemic lupus erythematosus patients using thromboelastography

“…The traditional parameters for screening coagulopathy include prothrombin time (PT) and activated partial thromboplastin time (aPTT). However, in Owaidah's study, among patients with positive lupus anticoagulant (LAC) status, 61% exhibited abnormal aPTT results that could not be corrected by mixing with normal plasma; moreover, the PT test yielded normal results in 90% cases . However, there is a limitation of the aPTT and PT test in these cases, as the results may reflect a certain product in the coagulation process, rather than the actual marker they are intended to reflect.…”

Intracerebral hemorrhage in a case of antiphospholipid antibody syndrome

“…The antiphospholipid syndrome (APS) may be associated with recurrent abortions and thrombotic cerebrovascular events (1)(2)(3)(4)(5)(6). Antiphospholipid antibody is an independent risk factor for stroke in especially young women (7).…”