Single-center study comparing computed tomography colonography with conventional colonoscopy

Roberts‐Thomson, Ian C.; Tucker, Graeme; Hewett, Peter; Cheung, Peter; Sebben, Ruben; Khoo, Ee Win; Marker, Julie; Clapton, Wayne

doi:10.3748/wjg.14.469

Cited by 18 publications

(8 citation statements)

References 29 publications

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“…We included 47 prospective studies involving 10,546 patients that compared CTC to the reference standard of CC or surgery [17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63]. Table 2 shows detailed information from individual studies.…”

Section: Resultsmentioning

confidence: 99%

Accuracy of Computed Tomographic Colonography for the Detection of Polyps and Colorectal Tumors: A Systematic Review and Meta-Analysis

et al. 2009

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Background: The real accuracy of computed tomographic colonography (CTC) is still unknown. Objective: To perform a meta-analysis of the diagnostic accuracy of CTC for the detection of polyps and colorectal tumors. Methods: Selection of studies:Studiesassessing the accuracy of CTC for the detection of colorectal polyps and tumors were selected. Data synthesis:Meta-analyses combining sensitivities, specificities and likelihood ratios (LRs) for the diagnosis of polyps and colorectal tumors were carried out. Results: Forty-seven studies, providing data of 10,546 patients, were included. Overall per-polyp sensitivity of CTC was 66% (64–68%), for polyps 6–9 mm in size it was 59% (56–61%), and 76% (73–79%) for polyps larger than 9 mm. Overall per-patient sensitivity was 69% (66–72%), for polyps 6–9 mm 60% (56–65%), and 83% (70–85%) for lesions larger than 9 mm. Overall CTC specificity was 83% (81–84%). Positive and negative LRs were 2.9 (1.8–4) and 0.38 (0.27–0.53), respectively; for polyps 6–9 mm in size, they were 3.8 (2.5–5.7) and 0.4 (0.27–0.59), and 12.3 (7.7–19.4) and 0.19 (0.12–0.3) for polyps larger than 9 mm. Conclusion: CTC is highly specific for the detection of colorectal polyps and tumors. Some studies reported high sensitivities, but the results of the studies were highly heterogeneous, while the studied variables explained only part of this discrepancy.

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Section: Resultsmentioning

confidence: 99%

Accuracy of Computed Tomographic Colonography for the Detection of Polyps and Colorectal Tumors: A Systematic Review and Meta-Analysis

et al. 2009

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“…We assessed patient preferences for CTC and colonoscopy in 130 patients who had recently undergone both tests as part of a diagnostic accuracy study [23]. Participants had indications appropriate for diagnostic colonoscopy, including bowel symptoms, positive faecal occult blood tests, or a family history of colorectal cancer.…”

Section: Methodsmentioning

confidence: 99%

“…We conducted a pilot study of the DCE in ten people who had experienced both CT colonography and colonoscopy as part of a pilot for the diagnostic accuracy trial [23]. Results indicated that respondents were able to understand attribute descriptions and levels and complete the 32 discrete choice questions without undue burden.…”

Section: Methodsmentioning

confidence: 99%

Preferences for CT Colonography and Colonoscopy as Diagnostic Tests for Colorectal Cancer: A Discrete Choice Experiment

et al. 2011

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Objective Computed tomography colonography (CTC) is an alternative diagnostic test to colonoscopy for colorectal cancer and polyps. The aim was to determine test characteristics important to patients and to examine trade-offs in attributes that patients are willing to accept in the context of diagnosis of colorectal cancer. Methods A discrete choice study to assess preferences of patients with clinical indications suspicious of colorectal cancer who experienced both CTC and colonoscopy as part of a diagnostic accuracy study in South Australia. Results were analysed using a mixed logit model and presented as odds ratios (OR) for preferring CTC over colonoscopy Results Colonoscopy was preferred over CTC as the need for a second procedure after CTC increased (odds ratio of preferring CTC to colonoscopy=0.013), as the likelihood of missing cancers or polyps increased (OR of CTC: colonoscopy=0.62) and as CTC test cost increased (OR of CTC: colonoscopy=0.65–0.80). CTC would be preferred to colonoscopy if a minimal bowel preparation was available (OR=1.7). Some patients were prepared to trade-off the diagnostic and therapeutic advantage of colonoscopy for a CTC study with a less intensive bowel preparation. Preferences also varied significantly with sociodemographic characteristics. Conclusions Despite CTC often being perceived as a preferred test, this may not always be the case. Informed decision making for diagnostic tests for colorectal cancer should include discussion of the benefits, downsides and uncertainties associated with alternative tests, as patients are willing and able to make trade-offs between what they perceive as the advantages and disadvantages of these diagnostic tests.

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“…Another disadvantage of virtual colonoscopy is the false negative or false positive rates. The most common reasons are inadequate colon preparation, inadequate distention and bulbous haustral fold (Hara et al, 2001;Halligan et al, 2006;Ferrucci, 2001;Roberts-Thomson et al, 2008). Screening in prone or supine position or administration of IV contrast agent might be helpful to avoid confusing polyps with residual fecal material.…”

Section: Advantages and Disadvantages Of Virtual Colonoscopymentioning

confidence: 99%

“…(Kim et al, 2007;Macari et al, 2011;Pedersen et al, 2003;Pescatore et al, 2000;Pickhardt et al, 2011;Pilch-Kowalczyk et al, 2004;Roberts-Thomson et al, 2008;Sutherland et al, 2011;White et al, 2009) (Fig 3,4). Virtual examinations carry the advantages including being relatively noninvasive, safe, and acceptable by clinicians (Ekci & Yildirim, 2009;Johnson & Dackman., 2000;Leksowski el al., 2011;McHugh et al, 2011;Vining, 1996).…”

Section: Advantages and Disadvantages Of Virtual Colonoscopymentioning

confidence: 99%

Non-Invasive Endoscopy Technique - Virtual Colonoscopy

Ekçı¹,

Gürses²,

Yıldırım³

2011

New Techniques in Gastrointestinal Endoscopy

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Single-center study comparing computed tomography colonography with conventional colonoscopy

Cited by 18 publications

References 29 publications

Accuracy of Computed Tomographic Colonography for the Detection of Polyps and Colorectal Tumors: A Systematic Review and Meta-Analysis

Accuracy of Computed Tomographic Colonography for the Detection of Polyps and Colorectal Tumors: A Systematic Review and Meta-Analysis

Preferences for CT Colonography and Colonoscopy as Diagnostic Tests for Colorectal Cancer: A Discrete Choice Experiment

Non-Invasive Endoscopy Technique - Virtual Colonoscopy

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