Single‐centre validation of the EASL‐CLIF Consortium definition of acute‐on‐chronic liver failure and CLIF‐SOFA for prediction of mortality in cirrhosis

Abstract

In our single-centre experience the CLIF-SOFA and the EASL-CLIF Consortium definition of ACLF proved to be strong predictors of short-term mortality in cirrhotic patients admitted for AD.

Cirrhosis in children and adolescents: An overview

“…In a study that evaluated a cohort of 192 patients admitted to the emergency department of a Brazilian tertiary hospital due to acute decompensation of cirrhosis, 46 (24%) fulfilled the EASL-CLIF Consortium criteria for ACLF. Bacterial infections were observed in 50% [94] . In children, the most common precipitating factor is infection.…”

Risk of different precipitating events for progressing to acute‐on‐chronic liver failure in HBV‐related cirrhotic patients

“…Acute‐on‐chronic liver failure (ACLF) in liver cirrhosis is a new clinical entity defined by the European Association for the Study of the Liver–Chronic Liver Failure Consortium as an acute deterioration of pre‐existing chronic liver disease (CLD) that is usually related to a precipitating event (PE), and is associated with an increased mortality at 3 months due to multiorgan failure (MOF) . The Chronic Liver Failure Consortium organ failure (CLIF‐C OF) score was originally proposed for diagnosing ACLF in patients with alcohol‐ and hepatitis C‐related liver cirrhosis (Western style) . The criteria have been validated in several retrospective cohort studies in Asian patients with ACLF, in which hepatitis B virus (HBV) infection remains the main etiology of cirrhosis .…”

A modified prognostic score for critically ill patients with cirrhosis: An observational study

“…In several recent studies, CLIF-SOFA had favorable performance (usually AUROCs > 0.8) and proved to be a strong predictor of mortality in patients with cirrhosis. 8,27,28 There is overlap between the components of MSCIC and CLIF-SOFA: HE, vasopressor use, serum bilirubin, and PT. Nevertheless, the MSCIC is more convenient and economical to use than that of CLIF-SOFA; this is because these easily measurable parameters are calculated in a qualitative approach in the MSCIC.…”