Single channel analysis of ketamine interaction with a quisqualate receptor

Nitrous oxide reversibly affects the kinetics, but not the conductance, of the qGluR channel of locust muscle. 0.5 atm N2O at 20.5 degrees C was without effect but both 1.5 and 2.7 atm significantly reduced the probability of the channel opening, the frequency of opening and the mean open time, and prolonged the mean closed time. 100 atm helium was without effect on these parameters, but when 98.5 atm He was combined with 1.5 atm N2O they, and the associated dwell time distributions, were restored to normal. 100 atm similarly combined with 2.7 atm N2O exerted a comparable trend which fell short of significance. The results are consistent with nitrous oxide binding to the channel with a significant molar volume increase, which pressure opposes. This suggests that nitrous oxide may cause conformational changes in the channel, and that the pressure reversal of nitrous oxide anaesthesia in animals could be caused by molecular antagonism.

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Spider toxins affecting glutamate receptors: Polyamines in therapeutic neurochemistry

Usherwood

Blagbrough

1991

Pharmacology & Therapeutics

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Single channel analysis of ketamine interaction with a quisqualate receptor

Cited by 6 publications

References 27 publications

Effects of high pressure on the channel gated by the quisqualate-sensitive glutamate receptor of locust muscle and its blockade by ketamine; a single-channel analysis

Effects of high pressure on the channel gated by the quisqualate-sensitive glutamate receptor of locust muscle and its blockade by ketamine; a single-channel analysis

The effects of nitrous oxide on a glutamate-gated ion channel and their reversal by high pressure; a single channel analysis

Spider toxins affecting glutamate receptors: Polyamines in therapeutic neurochemistry

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