Single-Chip Integration of Light-Emitting Diode, Waveguide and Micromirrors

Nagata, Takahiko; Namba, Tohru; Kuroda, Yasuhide; Miyake, Kouji; Miyamoto, Takuya; Yokoyama, Shiyoshi; Miyazaki, Seiichi; Koyanagi, Mitsumasa; Hirose, Masataka

doi:10.1143/jjap.34.1282

Cited by 12 publications

(4 citation statements)

References 2 publications

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“…This amounts to an external LED−photodetector optical coupling efficiency of 40%, since the LED quantum efficiency was measured to be 2 × 10 -7 . Considering the fiber thickness and the LED spectral width, which was approximately 500−800 nm (Figure B, curve 1), such coupling efficiency is excellent and should be compared with the 1% coupling efficiency obtained on thicker fibers when integrating compound semiconductor LEDs on silicon by microbonding techniques . Additionally, it can be further improved by increasing the deposited silicon dioxide thickness and the associated spacer radius.…”

Section: Resultsmentioning

confidence: 91%

A Monolithic Silicon Optoelectronic Transducer as a Real-Time Affinity Biosensor

et al. 2004

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An optical real-time affinity biosensor, which is based on a monolithic silicon optoelectronic transducer and a microfluidic module, is described. The transducer monolithically integrates silicon avalanche diodes as light sources, silicon nitride optical fibers, and p/n junction detectors and efficiently intercouples these elements through a self-alignment technique. The transducer surface is hydrophilized by oxygen plasma treatment, silanized with (3-aminopropyl)triethoxysilane and bioactivated through adsorption of the biomolecular probes. The use of a microfluidic module allows real-time monitoring of the binding reaction of the gold nanoparticle-labeled analytes with the immobilized probes. Their binding within the evanescent field at the surface of the optical fiber causes attenuated total reflection of the waveguided modes and reduction of the detector photocurrent. The biotin-streptavidin model assay was used for the evaluation of the analytical potentials of the device developed. Detection limits of 3.8 and 13 pM in terms of gold nanoparticle-labeled streptavidin were achieved for continuous- and stopped-flow assay modes, respectively. The detection sensitivity was improved by silver plating of the immobilized gold nanoparticles, and a detection limit of 20 fM was obtained after 20-min of silver plating. In addition, two different analytes, streptavidin and anti-mouse IgG, were simultaneously assayed on the same chip demonstrating the multianalyte potential of the sensor developed.

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Section: Resultsmentioning

confidence: 91%

A Monolithic Silicon Optoelectronic Transducer as a Real-Time Affinity Biosensor

et al. 2004

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“…Despite the aforementioned efforts for the integration of optical components onto the same chip with the transducer, the light source was not integrated and, even with the more compact broad-band sources, the device size remained substantial. Moreover, the light coupled to the device was just a little fraction of the incident light [125]. The only reliable solution provided so far to this problem was the implementation of silicon light emitting diodes (LED) integrated onto the same silicon chip with planar silicon nitride waveguides [126] as light sources.…”

Section: Monolithically Integrated Broad-band Optoelectronic Transducersmentioning

confidence: 99%

Label-Free Biosensors Based onto Monolithically Integrated onto Silicon Optical Transducers

2018

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The article reviews the current status of label-free integrated optical biosensors focusing on the evolution over the years of their analytical performance. At first, a short introduction to the evanescent wave optics is provided followed by detailed description of the main categories of label-free optical biosensors, including sensors based on surface plasmon resonance (SPR), grating couplers, photonic crystals, ring resonators, and interferometric transducers. For each type of biosensor, the detection principle is first provided followed by description of the different transducer configurations so far developed and their performance as biosensors. Finally, a short discussion about the current limitations and future perspectives of integrated label-free optical biosensors is provided.

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“…Despite the aforementioned efforts for integration of optical components onto the same chip with the transducer, the light source was not integrated and, even with the more compact broad-band sources, the device size remained substantial. Moreover, the light coupled to the device was just a little fraction of the incident light [116]. The only reliable solution provided so far to this problem was the implementation as light sources of silicon light emitting diodes (LED) integrated onto the same silicon chip with planar silicon nitride waveguides [117,[119][120][121][122][123][124][125][126][127][128][129][130][131].…”

Section: Monolithically Integrated Broad-band Optoelectronic Transducersmentioning

confidence: 99%

Label-Free Biosensors Based Onto Monolithically Integrated Onto Silicon Optical Transducers

Angelopoulou¹,

Kakabakos²,

Petrou³

2018

Preprint

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The article reviews the current status of label-free integrated optical sensors focusing on the evolution over the years of their analytical performance. At first a short introduction to the evanescent wave optics is provided followed by detailed description of the main categories of label-free optical sensors including sensors based on surface plasmon resonance (SPR), grating coupler, photonic crystals, ring resonators and interferometric transducers. After a short reference to SPR techniques, including localized SPR, integrated optical sensors i.e., grating-couplers, interferometers, photonic crystals, microring resonators are reviewed. For each type of sensor, the detection principle is first provided followed by description of the different transducer configurations so far developed and their performance as biosensors. Finally, a short discussion about the current limitations and future perspectives of integrated label-free biosensors optical sensors is provided

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Single-Chip Integration of Light-Emitting Diode, Waveguide and Micromirrors

Cited by 12 publications

References 2 publications

A Monolithic Silicon Optoelectronic Transducer as a Real-Time Affinity Biosensor

A Monolithic Silicon Optoelectronic Transducer as a Real-Time Affinity Biosensor

Label-Free Biosensors Based onto Monolithically Integrated onto Silicon Optical Transducers

Label-Free Biosensors Based Onto Monolithically Integrated Onto Silicon Optical Transducers

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