2023
DOI: 10.1101/2023.06.02.543464
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Single-component multilayered self-assembling protein nanoparticles displaying extracellular domains of matrix protein 2 as a pan-influenza A vaccine

Abstract: The development of a cross-protective pan-influenza A vaccine remains a significant challenge. Here, we designed and characterized single-component, self-assembling protein nanoparticles (1c-SApNPs) presenting the conserved extracellular domain of matrix protein 2 (M2e) from influenza A viruses of human and other hosts. Vaccination with tandem repeats of M2e (M2ex3) displayed on 1c-SApNPs demonstrated higher survival and lower weight loss compared to the soluble M2ex3 antigen against lethal challenges of H1N1 … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 114 publications
(309 reference statements)
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?