Single-Component Physical Hydrogels of Dendritic Molecules

Apartsin, Evgeny; Caminade, Anne‐Marie

doi:10.3390/jcs7010026

Cited by 4 publications

(8 citation statements)

References 59 publications

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“…The crosslinking mechanism is crucial in determining the structure, properties, and performance of the hydrogel. The two main types of crosslinking in polymer-based hydrogels are physical crosslinking [58,227,228] and chemical crosslinking [23,58,173,228].…”

Section: Classification Of Polymer-based Hydrogels Based On Crosslinkingmentioning

confidence: 99%

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Polymer-Based Hydrogels Applied in Drug Delivery: An Overview

Nguyen

Chien

Cường

2023

Gels

189

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Polymer-based hydrogels are hydrophilic polymer networks with crosslinks widely applied for drug delivery applications because of their ability to hold large amounts of water and biological fluids and control drug release based on their unique physicochemical properties and biocompatibility. Current trends in the development of hydrogel drug delivery systems involve the release of drugs in response to specific triggers such as pH, temperature, or enzymes for targeted drug delivery and to reduce the potential for systemic toxicity. In addition, developing injectable hydrogel formulations that are easily used and sustain drug release during this extended time is a growing interest. Another emerging trend in hydrogel drug delivery is the synthesis of nano hydrogels and other functional substances for improving targeted drug loading and release efficacy. Following these development trends, advanced hydrogels possessing mechanically improved properties, controlled release rates, and biocompatibility is developing as a focus of the field. More complex drug delivery systems such as multi-drug delivery and combination therapies will be developed based on these advancements. In addition, polymer-based hydrogels are gaining increasing attention in personalized medicine because of their ability to be tailored to a specific patient, for example, drug release rates, drug combinations, target-specific drug delivery, improvement of disease treatment effectiveness, and healthcare cost reduction. Overall, hydrogel application is advancing rapidly, towards more efficient and effective drug delivery systems in the future.

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Section: Classification Of Polymer-based Hydrogels Based On Crosslinkingmentioning

confidence: 99%

“…Physical crosslinking relies on reversible, non-covalent interactions between polymer chains to form a network structure [227,228]. These interactions can include hydrogen bonding, hydrophobic interactions, electrostatic interactions, or the physical entanglement of polymer chains [11,23].…”

Section: Classification Of Polymer-based Hydrogels Based On Crosslinkingmentioning

confidence: 99%

Polymer-Based Hydrogels Applied in Drug Delivery: An Overview

Nguyen

Chien

Cường

2023

Gels

189

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“…Multivalent interactions can be collectively much stronger than the corresponding monovalent interactions, in particular through multiple ligand-receptor interactions. Dendrimers, which are inherently multivalent species, are widely used in different fields of science and technology, such as catalysis [31], biomaterials [32,33], regenerative and cell biology [34][35][36][37], and nanomedicine [38][39][40][41].…”

Section: The Use Of Dendrimers For Biomedical Applications 21 Dendrim...mentioning

confidence: 99%

Dendrimer-Mediated Delivery of DNA and RNA Vaccines

et al. 2023

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DNA and RNA vaccines (nucleic acid-based vaccines) are a promising platform for vaccine development. The first mRNA vaccines (Moderna and Pfizer/BioNTech) were approved in 2020, and a DNA vaccine (Zydus Cadila, India), in 2021. They display unique benefits in the current COVID-19 pandemic. Nucleic acid-based vaccines have a number of advantages, such as safety, efficacy, and low cost. They are potentially faster to develop, cheaper to produce, and easier to store and transport. A crucial step in the technology of DNA or RNA vaccines is choosing an efficient delivery method. Nucleic acid delivery using liposomes is the most popular approach today, but this method has certain disadvantages. Therefore, studies are actively underway to develop various alternative delivery methods, among which synthetic cationic polymers such as dendrimers are very attractive. Dendrimers are three-dimensional nanostructures with a high degree of molecular homogeneity, adjustable size, multivalence, high surface functionality, and high aqueous solubility. The biosafety of some dendrimers has been evaluated in several clinical trials presented in this review. Due to these important and attractive properties, dendrimers are already being used to deliver a number of drugs and are being explored as promising carriers for nucleic acid-based vaccines. This review summarizes the literature data on the development of dendrimer-based delivery systems for DNA and mRNA vaccines.

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“…The seminal work by Gitsov and Zhu on the synthesis of amphiphilic dendritic hydrogels based on PEG and dendritic poly(benzyl ethers) [ 12 ] led to the design of many other dendritic networks based on PAMAM, PAMAM-OS, PPI, Poly-L-lysine, glycerol or polyester (bis-MPA). These include covalent networks [ 13 ], physical networks [ 14 ] and mixed inter-penetrating networks (IPN) [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Fine-Tuning the Amphiphilic Properties of Carbosilane Dendritic Networks towards High-Swelling Thermogels

Muñoz-Sánchez,

Barrios-Gumiel,

de la Mata

et al. 2024

Pharmaceutics

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Dendritic hydrogels based on carbosilane crosslinkers are promising drug delivery systems, as their amphiphilic nature improves the compatibility with poorly water-soluble drugs. In this work, we explored the impact of the complementary polymer on the amphiphilic properties of the dendritic network. Different polymers were selected as precursors, from the highly lipophilic propylene glycol (PPG) to the hydrophilic polyethylene glycol (PEG), including amphiphilic Pluronics L31, L35 and L61. The dithiol polymers reacted with carbosilane crosslinkers through UV-initiated thiol–ene coupling (TEC), and the resultant materials were classified as non-swelling networks (for PPG, PLUL31 and PLUL61) and high-swelling hydrogels (for PEG and PLUL35). The hydrogels exhibited thermo-responsive properties, shrinking at higher temperatures, and exhibited an intriguing drug release pattern due to internal nanostructuring. Furthermore, we fine-tuned the dendritic crosslinker, including hydroxyl and azide pendant groups in the focal point, generating functional networks that can be modified through degradable (ester) and non-degradable (triazol) bonds. Overall, this work highlighted the crucial role of the amphiphilic balance in the design of dendritic hydrogels with thermo-responsive behavior and confirmed their potential as functional networks for biomedical applications.

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Single-Component Physical Hydrogels of Dendritic Molecules

Cited by 4 publications

References 59 publications

Polymer-Based Hydrogels Applied in Drug Delivery: An Overview

Polymer-Based Hydrogels Applied in Drug Delivery: An Overview

Dendrimer-Mediated Delivery of DNA and RNA Vaccines

Fine-Tuning the Amphiphilic Properties of Carbosilane Dendritic Networks towards High-Swelling Thermogels

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