Single-Compound Libraries of Organic Materials: Parallel Synthesis and Screening of Fluorescent Dyes

An efficient methodology for the synthesis of 3-styryl coumarins

“…To substrate 2, were applied several Heck catalyst systems including those referred in literature [18][19][20] but the results were as discouraging as those here presented in Table 1 (route A). These results are consistent with the reactivity of coumarins at the 3-position that is largely dependent on the substitution pattern as any change on the arrangement of substituents leads to unpredictable results.…”

“…Previously, 18 the palladium-catalysed insertion of 3-bromocoumarin into a number of alkenes, cycloalkenes and alkynes was already tried. More recently the approach of Bäuerle and co-workers 19 for the parallel synthesis of a 3-substituted coumarin compounds library rely also on palladium catalyzed reaction between 3-bromocoumarin and appropriated arylvinyl substrates. This work is however limited to the unsubstituted 3-bromocoumarin or to nitrogen substituted ones.…”

Fluorogenic click reaction

“…[19][20][21][22][23][24] The CuAAC reaction is distinguished from others by its mild reaction conditions and high transformation efficiency regardless of the structures of azides and alkynes, which makes it an ideal reaction to synthesize fluorescent dyes in a combinatorial manner.…”

Microwave-assisted Fe3O4 nanoparticles catalyzed synthesis of chromeno[1,6]naphthyridines in aqueous media

“…While a considerable number of naphthyridines fused with five-membered rings has been described in literature [13][14], corresponding derivatives condensed with six-membered heterocycles have been less investigated [15][16]. There are also few synthetic methods available in literature for the synthesis of chromeno [1,6]naphthyridines [17][18][19][20].…”