Single-dose cefonicid therapy for urinary tract infections

Pontzer, Raymond; Krieger, Rachel; Boscia, Jerome A.; McNamee, William; Levison, Matthew E.; Kaye, Donald

doi:10.1128/aac.23.6.814

Cited by 24 publications

(2 citation statements)

References 13 publications

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“…15:443, 1981). Cephalosporins are effective against most common urinary tract pathogens (16), but their administration as a single dose for UTIs is controversial (5,15,23,27). Ceftriaxone is a new, parenterally administered cephalosporin with an expanded antibacterial activity (6,10,21).…”

mentioning

confidence: 99%

Single-dose ceftriaxone versus multiple-dose trimethoprim-sulfamethoxazole in the treatment of acute urinary tract infections

Iravani¹,

Richard²

1985

Antimicrob Agents Chemother

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Fifty-four college women with symptoms of lower urinary tract infections were randomly treated, 25 with 500 mg of ceftriaxone in a single intramuscular dose and 29 with 160 mg of trimethoprim-800 mg of sulfamethoxazole orally twice daily for 7 days. At 1 week after treatment, 23 patients (92%) in the ceftriaxone group and 28 patients (96%) in the trimethoprim-sulfamethoxazole group were cured. Responses of the patients with positive or negative antibody-coated bacteria tests were not significantly different. Four patients (16%) in the ceftriaxone group developed diarrhea and malaise. One patient (4%) in the trimethoprim-sulfamethoxazole group had medication discontinued because of headaches. Leukopenia was found in one patient (4%) in the ceftriaxone group and four patients (14%) in the trimethoprim-sulfamethoxazole group.Single-dose regimens of a variety of antimicrobial agents have been found effective in the treatment of acute uncomplicated urinary tract infections (UTIs) (2, 13, 24; A. Iravani and G. A. Richard, Pediatr. Res. 15:443, 1981). Cephalosporins are effective against most common urinary tract pathogens (16), but their administration as a single dose for UTIs is controversial (5,15,23,27). Ceftriaxone is a new, parenterally administered cephalosporin with an expanded antibacterial activity (6,10,21). Its plasma elimination half-life is about 8 h (four times longer than that of other cephalosporins), and it is excreted in its active form in high concentrations in the urine (7,25,26,28).The purposes of this trial were (i) to compare the efficacy and safety of a single intramuscular dose of ceftriaxone with multiple oral doses of trimethoprim-sulfamethoxazole for treatment of UTIs in college women, (ii) to relate therapeutic responses to the results of antibody-coated bacteria test (ACBT), and (iii) to assess the emergence of resistant Enterobacteriaceae in the urogenital and rectal areas. MATERIALS AND METHODSPatient criteria. Fifty-four college women with symptoms of acute cystitis were enrolled in the study at the Kidney Clinic of the University of Florida Student Health Service. The major criteria for inclusion in this study were (i) the presence of at least one bacterium in each random highpower microscopic field of uncentrifuged and unstained samples of two urine specimens and (ii) 2105 CFU of the same bacterium per ml in each of the two urine specimens. Excluded were pregnant or lactating women, patients who had received antimicrobial therapy during the preceding week, and those with fever (238°C), flank pain, impaired renal or liver function, radiographically proven obstructive uropathy, history of glucose 6-phosphate dehydrogenase deficiency, or allergy to cephalosporins, trimethoprim, or sulfonamides.Collection and processing of specimens. Two clean-catch, midstream urine specimens were obtained from each patient within 24 h before treatment began. Before and 1 week after the end of treatment, specimens were collected from vagi-* Corresponding author. nal, periurethral, and rectal areas by C...

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confidence: 99%

Single-dose ceftriaxone versus multiple-dose trimethoprim-sulfamethoxazole in the treatment of acute urinary tract infections

Iravani¹,

Richard²

1985

Antimicrob Agents Chemother

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“…basis. 41,42 Cefonicid has a half-life of 4 hours, and is used in a single daily dose for the treatment of infections 55 and for preoperative prophylaxis. 41 Comparable outcomes result from a single dose of 1 g vs. 4 doses of 1 to 2 g of cefoxitin in cholecystectomy, colorectal surgery, hysterectomy, and cesarean section.…”

Section: Second-generation Agentsmentioning

confidence: 99%

The Cephalosporin Antibiotic Agents — II. First- and Second-Generation Agents

Td¹

1984

Infect. Control

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The first article in this series discussed the cephalosporin antibiotic agents as a class, including the similarities in their structure, antimicrobial action, and toxicity. Part II focuses on the difference between commercially available first- and second-“generation” agents.The cephalosporins are classified using various criteria, including vulnerability to beta-lactamase hydrolysis and antibacterial activity. The latter classification is based on the in vitro activity of the individual agents, with each succeeding “generation” possessing a greater spectrum of activity than the previous generation(s).

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Single-Dose Antibiotic Treatment for Uncomplicated Urinary Tract Infections

Philbrick¹

1985

Arch Intern Med

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Single-dose cefonicid therapy for urinary tract infections

Cited by 24 publications

References 13 publications

Single-dose ceftriaxone versus multiple-dose trimethoprim-sulfamethoxazole in the treatment of acute urinary tract infections

Single-dose ceftriaxone versus multiple-dose trimethoprim-sulfamethoxazole in the treatment of acute urinary tract infections

The Cephalosporin Antibiotic Agents — II. First- and Second-Generation Agents

Single-Dose Antibiotic Treatment for Uncomplicated Urinary Tract Infections

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